FCGBP
FCGBP (Fc gamma binding protein, also called IgGFc-binding protein, FC(GAMMA)BP or FcgammaBP) is a secreted protein that may help maintain mucosal structure as a gel-like component of the mucosa. It is also predicted to act as a structural constituent of the extracellular matrix. Browse Assay Genie's current range of FCGBP research reagents below, or read on for the biology behind the target.
FCGBP is a secreted protein. The UniProt annotation describes its function cautiously: it may be involved in the maintenance of the mucosal structure, acting as a gel-like component of the mucosa. In other words, the available evidence points to a structural role in the mucosal layer, and not to enzymatic activity or to signalling through a defined receptor.
This fits the computational annotation summarised by NCBI Gene, which predicts that FCGBP is an extracellular matrix structural constituent and reports that it is located in extracellular exosomes. Together, these descriptions place the FCGBP protein outside the cell, either within secreted matrix-like material or associated with exosomes. Researchers studying mucosal barriers, extracellular matrix composition or exosome cargo may therefore encounter it in their work.
The official HGNC name of the FCGBP gene is Fc gamma binding protein, and the UniProt recommended name is IgGFc-binding protein. The symbol has been used with the aliases FC(GAMMA)BP and FcgammaBP, and the gene was previously named Fc fragment of IgG binding protein. These names reflect the origin of the protein as an IgG Fc-binding factor. The FCGBP gene maps to chromosome 19q13.2. No HGNC gene group is assigned, and no enzyme classification applies.
Because the functional annotation for FCGBP is still described in tentative terms ("may be involved" and "predicted to be"), it is best treated as a candidate component of mucosal and extracellular structures. Experimental work, such as an FCGBP antibody for localisation studies or an FCGBP ELISA kit for measuring the secreted protein, can help to clarify its role.
FCGBP may help maintain mucosal structure as a gel-like component of the mucosa, making it a candidate for studies of mucosal architecture.
FCGBP is predicted to be a structural constituent of the extracellular matrix, relevant to work on secreted matrix components.
FCGBP is reported as located in extracellular exosomes, so it is a point of interest when profiling exosome-associated proteins.
As a secreted protein annotated as IgGFc-binding, FCGBP is a subject for work on extracellular proteins and their structural roles.
UniProt states that FCGBP may be involved in maintaining mucosal structure as a gel-like component of the mucosa. NCBI Gene adds that it is predicted to be an extracellular matrix structural constituent. Both statements are tentative, so its role is best described as structural rather than catalytic.
The HGNC name is Fc gamma binding protein, and UniProt calls it IgGFc-binding protein. Aliases include FC(GAMMA)BP and FcgammaBP. The previous HGNC name was Fc fragment of IgG binding protein. Searching under any of these names should help when reviewing the literature.
The source annotations used here do not describe a disease association, and mouse and rat orthologs are not specified in the data. Anyone planning cross-species work should confirm orthologs independently and check the datasheet of any product for its validated reactivity.
Other mucosal, extracellular matrix and Fc-binding targets that may be of interest alongside FCGBP.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y6R7; product specifications from Assay Genie datasheets.