KLF14
KLF14 (KLF transcription factor 14, also known as BTEB5) is a nuclear member of the Krueppel-like family of transcription factors. It acts as a transcriptional co-repressor and is induced by TGF-beta to repress TGF-beta receptor II gene expression. Browse Assay Genie's current range of KLF14 research reagents below, or read on for the biology behind the target.
KLF14 is a transcription factor that functions as a transcriptional co-repressor. According to the NCBI Gene summary, it is induced by transforming growth factor-beta (TGF-beta) and, in turn, represses expression of the TGF-beta receptor II gene. This places the KLF14 protein within a feedback relationship with TGF-beta signalling, and makes it a useful subject for studies of how transcriptional repression shapes cytokine responses.
The KLF14 gene is intronless and encodes a member of the Kruppel-like family of transcription factors. UniProt classifies the protein in the Sp1 C2H2-type zinc-finger protein family, and HGNC places it in the zinc fingers C2H2-type group and the KLF transcription factors group. The protein is located in the nucleus, consistent with its role in regulating gene expression. The mouse ortholog is Klf14.
A notable feature of the gene is its imprinted expression: it is expressed from the maternal allele in embryonic and extra-embryonic tissues. This parent-of-origin pattern distinguishes KLF14 from many other KLF family members and is a focus for researchers interested in genomic imprinting. The previous HGNC name was Kruppel like factor 14, and the gene has also been known by the symbol BTEB5. Other KLF family members, such as KLF2, KLF4 and KLF11, are often studied alongside it to compare how related factors regulate transcription.
KLF14 is induced by TGF-beta and represses TGF-beta receptor II gene expression, making it relevant to studies of pathway feedback.
KLF14 functions as a transcriptional co-repressor, providing a model for investigating how KLF family members silence target genes.
The KLF14 gene shows imprinted expression from the maternal allele in embryonic and extra-embryonic tissues.
As a member of the Sp1 C2H2-type zinc-finger family, KLF14 is studied alongside other KLF transcription factors to compare their roles.
KLF14 is a transcription factor that works as a transcriptional co-repressor. It is induced by TGF-beta and represses expression of the TGF-beta receptor II gene. The protein is found in the nucleus, where it acts on gene expression.
KLF14 stands for KLF transcription factor 14, and UniProt names the protein Krueppel-like factor 14. The alias BTEB5 is also used, and the previous HGNC name was Kruppel like factor 14. The mouse ortholog is called Klf14.
Yes. The NCBI Gene summary states that KLF14 shows imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. It is also an intronless gene, and check the datasheet of any product for its validated reactivity.
Other Krueppel-like factor transcription factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8TD94; product specifications from Assay Genie datasheets.