TRAF5
TRAF5 (TNF receptor-associated factor 5, also known as RNF84) is a cytoplasmic adapter protein and signal transducer that links members of the tumour necrosis factor receptor family to downstream signalling pathways. It mediates activation of NF-kappa-B and probably JNK. Browse Assay Genie's current range of TRAF5 research reagents below, or read on for the biology behind the target.
TRAF5 is an adapter protein and signal transducer that connects members of the tumour necrosis factor (TNF) receptor family to different signalling pathways. It does so by associating with the receptor cytoplasmic domain and with kinases. TRAF5 mediates activation of NF-kappa-B and probably JNK, and it seems to be involved in apoptosis. It also plays a role in mediating NF-kappa-B activation by EIF2AK2/PKR.
The scaffold protein encoded by the TRAF5 gene belongs to the TNF receptor-associated factor (TRAF) family, A subfamily. It contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger and two TRAF-type zinc fingers. TRAF proteins associate with, and mediate signal transduction from, members of the TNF receptor superfamily. TRAF5 is one component of a multiple protein complex that binds the cytoplasmic domains of TNF receptors and mediates TNF-induced activation. The protein is found in the cytoplasm, including the cytosol.
HGNC places TRAF5 in the groups of ring finger proteins, TNF receptor associated factors, TRAF-type zinc fingers and RING finger E3 ubiquitin protein ligases. RNF84 is a previous symbol for the gene. Multiple transcript variants encoding different isoforms have been reported. The mouse ortholog is Traf5, which allows the protein to be studied in murine models.
TRAF5 links TNF receptor family members to downstream pathways through association with receptor cytoplasmic domains and kinases.
TRAF5 mediates NF-kappa-B activation, including activation driven by EIF2AK2/PKR, making it a useful node for studying this pathway.
TRAF5 probably mediates JNK activation, so it is relevant to work on stress and receptor-linked kinase signalling.
TRAF5 seems to be involved in apoptosis, connecting TNF receptor signalling to cell fate decisions.
TRAF5 is an adapter protein and signal transducer. It links tumour necrosis factor receptor family members to signalling pathways by binding receptor cytoplasmic domains and kinases. It mediates NF-kappa-B activation, probably JNK activation, and seems to be involved in apoptosis.
The TRAF5 gene, named for TNF receptor associated factor 5, has the previous symbol RNF84. NCBI Gene reports multiple transcript variants that encode different isoforms. HGNC classes it among ring finger proteins and TRAF-type zinc finger proteins.
TRAF5 belongs to the TNF receptor-associated factor family, A subfamily, and has a mouse ortholog, Traf5. Related family members include TRAF2, TRAF3, TRAF4, TRAF6 and TRAF7. Check the datasheet of any product for its validated reactivity.
Other TNF receptor-associated factors that share the TRAF domain architecture and act in TNF receptor family signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O00463; product specifications from Assay Genie datasheets.