SAA
SAA (serum amyloid A1, encoded by SAA1 and also known as PIG4 or TP53I4) is a secreted apolipoprotein of the serum amyloid A family. It is a major acute phase protein, expressed at high levels in response to inflammation and tissue injury. Browse Assay Genie's current range of SAA research reagents below, or read on for the biology behind the target.
SAA is a major acute phase protein. Its levels rise sharply during inflammation and after tissue injury, which makes it a frequent subject in studies of the acute phase response. The protein also has a role in HDL metabolism and cholesterol homeostasis, linking inflammatory signalling to lipid biology. In addition, antimicrobial activity against S. aureus and E. coli resides in the N-terminal portion of the mature protein.
The SAA gene, SAA1, encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to give the mature, secreted protein. Alternate splicing produces multiple transcript variants, but all of them encode the same protein. A pseudogene of SAA1 is found on chromosome 11. The mouse ortholog is Saa1. HGNC places the gene in the receptor ligands group, and UniProt assigns the protein to the SAA family.
High levels of SAA are associated with chronic inflammatory diseases, including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. The protein may also be a potential biomarker for certain tumours. Researchers studying inflammation, lipoprotein biology and disease biomarkers therefore often measure SAA, using approaches such as an SAA antibody or an SAA ELISA kit. Aliases for the gene include PIG4 and TP53I4.
SAA is a major acute phase protein that is highly expressed in response to inflammation and tissue injury.
SAA is an apolipoprotein that plays an important role in HDL metabolism and cholesterol homeostasis.
High SAA levels are associated with atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease.
The N-terminal portion has activity against S. aureus and E. coli, and SAA may be a potential tumour biomarker.
SAA is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. It also plays an important role in HDL metabolism and cholesterol homeostasis. Its N-terminal portion has antimicrobial activity against S. aureus and E. coli.
The gene symbol is SAA1, and the protein is called serum amyloid A1 or serum amyloid A-1 protein. Aliases include PIG4, TP53I4 and SAA. Alternate splicing gives several transcript variants, but they all encode the same protein.
High SAA levels are associated with atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease, and it may be a tumour biomarker. The mouse ortholog is Saa1. Check the datasheet of any product for its validated reactivity.
Other serum amyloid A family members and related proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P0DJI8; product specifications from Assay Genie datasheets.