FBLN2
FBLN2 (fibulin 2) is a secreted extracellular matrix protein that belongs to the fibulin family. It binds calcium and a range of extracellular ligands, and it may act as an adapter between fibrillin-1 and elastin. Browse Assay Genie's current range of FBLN2 research reagents below, or read on for the biology behind the target.
FBLN2 is an extracellular matrix protein of the fibulin family. It is secreted into the extracellular space, where it binds calcium and various extracellular ligands. Its binding to fibronectin and some other ligands is calcium dependent. It may also act as an adapter that mediates the interaction between fibrillin-1 (FBN1) and elastin (ELN), which places it at the junction between microfibrils and elastic fibres in the matrix.
The human FBLN2 gene encodes the fibulin-2 protein, and the mouse ortholog is Fbln2. According to the NCBI Gene summary, alternatively spliced transcript variants encoding different isoforms have been identified, so researchers studying the FBLN2 protein should consider which form they are measuring.
Fibulin 2 is classified by HGNC in the fibulins gene group. Related members of the group include FBLN1, FBLN5 and FBLN7. The NCBI Gene summary notes that FBLN2 may play a role during organ development, in particular during the differentiation of heart, skeletal and neuronal structures. This makes it a relevant target for work on matrix assembly, calcium-dependent ligand interactions and developmental biology.
FBLN2 is a secreted matrix protein that binds calcium and extracellular ligands, so it is a useful target for studying matrix composition and organisation.
FBLN2 may act as an adapter linking fibrillin-1 and elastin, which makes it of interest in studies of microfibril and elastin interactions.
FBLN2 may contribute to the differentiation of heart, skeletal and neuronal structures during organ development.
FBLN2 binds fibronectin and other ligands in a calcium-dependent manner, providing a model for studying matrix protein interactions.
FBLN2 is a secreted extracellular matrix protein that binds calcium and various extracellular ligands. Its binding to fibronectin and some other ligands is calcium dependent. It may act as an adapter between FBN1 and ELN, and it may contribute to organ development.
The HGNC name is fibulin 2, and UniProt lists the protein as Fibulin-2. No alternative gene symbols are recorded. NCBI Gene reports that alternatively spliced transcript variants encode different isoforms, so check which isoform is relevant to your work.
The mouse has an ortholog named Fbln2. FBLN2 belongs to the fibulin family, which also includes FBLN1, FBLN5 and FBLN7 in humans. Check the datasheet of any product for its validated reactivity.
Other fibulin family members with products at Assay Genie, useful for studying extracellular matrix proteins.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P98095; product specifications from Assay Genie datasheets.