CHL1
CHL1 (cell adhesion molecule L1 like, also known as CALL or L1CAM2) is an extracellular matrix and cell adhesion protein of the L1 family. It contributes to nervous system development and synaptic plasticity. Browse Assay Genie's current range of CHL1 research reagents below, or read on for the biology behind the target.
CHL1 is an extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. It also contributes to the neuronal positioning of pyramidal neurons and to the regulation of both interneuron number and the efficacy of GABAergic synapses. CHL1 may help regulate cell migration in nerve regeneration and cortical development, and it potentiates integrin-dependent cell migration towards extracellular matrix proteins. At the cell surface it recruits ANK3 to the plasma membrane.
The CHL1 protein is found at the cell membrane and as a secreted form in the extracellular matrix. It belongs to the immunoglobulin superfamily and the L1/neurofascin/NgCAM family, and the gene is grouped by HGNC with fibronectin type III domain containing, I-set domain containing and Ig-like cell adhesion molecule families. NCBI describes it as a neural recognition molecule that may be involved in signal transduction pathways. Alternate splicing of the CHL1 gene produces both coding and non-coding variants. The mouse ortholog is Chl1.
The gene was originally named for its homology to L1CAM, as a close homologue of L1, and it has also been listed as CALL, L1CAM2, FLJ44930 and MGC132578. Deletion of one copy of the gene may be responsible for mental defects in patients with 3p- syndrome, and the protein may also play a role in the growth of certain cancers.
CHL1 plays a role in nervous system development, including the neuronal positioning of pyramidal neurons and cortical development.
Soluble and membranous CHL1 promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death.
CHL1 is implicated in synaptic plasticity, interneuron number and the efficacy of GABAergic synapses.
CHL1 potentiates integrin-dependent migration towards extracellular matrix proteins and may play a role in the growth of certain cancers.
CHL1 is an extracellular matrix and cell adhesion protein involved in nervous system development and synaptic plasticity. It promotes neurite outgrowth, suppresses neuronal cell death, potentiates integrin-dependent cell migration and recruits ANK3 to the plasma membrane.
CHL1 stands for cell adhesion molecule L1 like. Aliases and previous symbols include CALL, L1CAM2, FLJ44930 and MGC132578. UniProt lists the protein as neural cell adhesion molecule L1-like protein. Earlier names described it as a close homologue of L1. Alternate splicing gives coding and non-coding variants.
NCBI Gene reports that deletion of one copy of the CHL1 gene may be responsible for mental defects in patients with 3p- syndrome. The protein may also play a role in the growth of certain cancers. The mouse ortholog is Chl1; check the datasheet of any product for its validated reactivity.
Other L1 family adhesion molecules and binding partners relevant to neural development and synaptic research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O00533; product specifications from Assay Genie datasheets.