TNFRSF6B
TNFRSF6B (tumour necrosis factor receptor superfamily member 6B, also known as DcR3, DCR3, TR6 and M68) is a secreted decoy receptor of the TNF receptor superfamily. It binds and neutralises TNF-family ligands, including FASLG, TNFSF14/LIGHT and TNFSF15. Browse Assay Genie's current range of TNFRSF6B research reagents below, or read on for the biology behind the target.
TNFRSF6B works as a soluble decoy receptor. Rather than transmitting a signal at the cell surface, the secreted protein binds the TNF-family ligands TNFSF14/LIGHT, TNFSF15 and FASLG and neutralises them. This prevents the ligands from reaching their cognate receptors, and so blocks apoptosis and other immune-signalling pathways. The protein is postulated to have a regulatory role in suppressing cell death mediated by FasL and LIGHT, and it competes with death receptors for ligand binding.
The TNFRSF6B gene belongs to the tumour necrosis factor receptor superfamily, the HGNC gene group to which it is assigned. Unlike many family members, its product is secreted rather than membrane-anchored. This makes the TNFRSF6B protein a useful model for how soluble receptors shape ligand availability in cell-death and immune pathways.
Over-expression of the gene has been noted in gastrointestinal tract tumours, which is one reason researchers study it in the context of immune evasion and cell-death regulation. The symbol was previously described as tumour necrosis factor receptor superfamily, member 6b, decoy, and the protein is widely known as DcR3 or TR6. Read-through transcription from the neighbouring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. Researchers who search for a DcR3 antibody or a TNFRSF6B ELISA kit are usually studying ligand neutralisation, apoptosis control or tumour biology.
TNFRSF6B is postulated to suppress FasL- and LIGHT-mediated cell death, making it a focus for studies of how apoptosis is regulated.
It competes with death receptors for ligand binding, offering a model of how soluble receptors neutralise TNF-family ligands.
By neutralising TNFSF14/LIGHT, TNFSF15 and FASLG, it blocks ligand access to cognate receptors and modulates immune-signalling pathways.
Over-expression of the gene has been noted in gastrointestinal tract tumours, linking it to cancer biology investigations.
TNFRSF6B is a soluble decoy receptor. It binds and neutralises the TNF-family ligands TNFSF14/LIGHT, TNFSF15 and FASLG, preventing them from engaging their cognate receptors. In this way it blocks apoptosis and other immune-signalling pathways, and it competes with death receptors for ligand binding.
TNFRSF6B is also called DcR3, DCR3, TR6 and M68. Its earlier HGNC name was tumour necrosis factor receptor superfamily, member 6b, decoy. UniProt lists the protein as tumour necrosis factor receptor superfamily member 6B, a secreted protein.
NCBI Gene notes that over-expression of TNFRSF6B has been observed in gastrointestinal tract tumours. Its proposed role in suppressing FasL- and LIGHT-mediated cell death is consistent with this. Mouse and rat orthologues are not specified here, so check the datasheet of any product for its validated reactivity.
Other members of the tumour necrosis factor receptor superfamily with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95407; product specifications from Assay Genie datasheets.