TNFRSF6B belongs to the tumour necrosis factor receptor superfamily. TNFRSF6B might be involved in FasL- and LIGHT-induced cell death by regulating the activity of proteins that promote apoptosis. TNFRSF6B is a decoy receptor that competes for ligand binding with death receptors. TNFRSF6B has been found to be overexpressed in gastrointestinal tumours. crescentic glomerulonephritis and dyskeratosis congenital are all diseases linked to TNFRSF6B. TNFR1 pathway and cytokine signalling in the immune system are TNFRSF6B related pathways. Human DCR3/TNFRSF6B Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human DCR3/TNFRSF6B Recombinant Protein (RPES5239)
Product Code:
RPES5239
Size:
100µg
Species:
Human
Expressed Host:
Baculovirus-Insect Cells
Synonyms:
DCR3,DJ583P15.1.1,M68,M68E,TNFRSF6B,TR6
Accession:
O95407
Sequence:
Met 1-His300
Fusion tag:
C-Fc
Activity:
Measured by its ability to inhibit Fas Ligand induced apoptosis of Jurkat human acute T cell leukemia cells.The ED50 for this effect is typically 0.01-0.05 µg/mL in the presence of 20 ng/mL recombinant human Fas Ligand.
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human DCR3 (O95407)(Met1-His300) was expressed with the Fc region of human IgG1 at the C-terminus.
Purity:
> 85 % as determined by reducing SDS-PAGE.
Mol Mass:
56.4 kDa
AP Mol Mass:
65 kDa
Formulation:
Lyophilized from sterile 100mM Glycine, 10mM NaCl, pH 7.0.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
