PPP1R14C
PPP1R14C (protein phosphatase 1 regulatory inhibitor subunit 14C) is an inhibitor of protein phosphatase-1 (PP1) and a member of the PP1 inhibitor family. It is also known as CPI17-like, NY-BR-81 and KEPI. Browse Assay Genie's current range of PPP1R14C research reagents below, or read on for the biology behind the target.
The degree of protein phosphorylation is set by a balance between protein kinase and phosphatase activities. Protein phosphatase-1 (PP1) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction and cell division. PPP1R14C acts on this balance as an inhibitor of PP1, and UniProt annotates it as an inhibitor of the PP1 catalytic subunit PPP1CA.
The PPP1R14C gene encodes protein phosphatase 1 regulatory subunit 14C, which belongs to the PP1 inhibitor family. In the HGNC classification it sits within the group of protein phosphatase 1 regulatory subunits. UniProt reports the protein in the cytoplasm and at the membrane. Mouse and rat both carry an orthologous gene named Ppp1r14c, so the target can be studied in common rodent models.
The protein is known by several names. CPI17-like reflects its relationship to CPI17, another member of the PP1 inhibitor family, while NY-BR-81 and KEPI are further aliases. The earlier HGNC name was protein phosphatase 1, regulatory (inhibitor) subunit 14C. The inhibitory role of PPP1R14C towards PP1 was described by Liu and colleagues in 2002. For researchers working on phosphatase regulation, PPP1R14C is a useful point of entry into how PP1 activity is restrained within signalling networks.
PPP1R14C inhibits PP1, a signal-transducing phosphatase, making it relevant to studies of how kinase and phosphatase activities balance protein phosphorylation.
As a member of the PP1 inhibitor family and the PP1 regulatory subunit gene group, it is a model for comparing PP1 control mechanisms.
PP1 influences neuronal activity and muscle contraction, so its inhibitor PPP1R14C is of interest in these contexts.
PP1 affects protein synthesis, metabolism and cell division, and PPP1R14C provides a way to examine how its activity is restrained.
PPP1R14C is an inhibitor of protein phosphatase-1 (PP1). UniProt annotates it as an inhibitor of the PP1 catalytic subunit PPP1CA. PP1 is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction and cell division.
PPP1R14C is also called CPI17-like, NY-BR-81 and KEPI. Its full HGNC name is protein phosphatase 1 regulatory inhibitor subunit 14C, and it was previously named protein phosphatase 1, regulatory (inhibitor) subunit 14C. UniProt lists it as Protein phosphatase 1 regulatory subunit 14C.
Yes. Both mouse and rat have an orthologous gene named Ppp1r14c, so the human PPP1R14C protein can be investigated in rodent systems. Cross-species work still needs care, so check the datasheet of any product for its validated reactivity.
Other PP1 catalytic and regulatory subunits, PP1 inhibitors and related protein phosphatases with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8TAE6; product specifications from Assay Genie datasheets.