ALDOC
ALDOC (aldolase, fructose-bisphosphate C) is a class I fructose-bisphosphate aldolase that catalyses the reversible cleavage of fructose 1,6-bisphosphate in glycolysis and gluconeogenesis. It was previously named aldolase C, fructose-bisphosphate, and is enriched in the brain. Browse Assay Genie's current range of ALDOC research reagents below, or read on for the biology behind the target.
ALDOC is a glycolytic enzyme that catalyses the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphates. This reaction places the ALDOC protein at a central step in both glycolysis and gluconeogenesis. According to the NCBI Gene summary, the enzyme performs the reversible aldol cleavage of fructose 1,6-bisphosphate and fructose 1-phosphate, yielding dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively.
The ALDOC gene encodes a member of the class I fructose-bisphosphate aldolase family. In HGNC it is placed in the aldolase, fructose-bisphosphate family gene group. Unlike a ubiquitous metabolic enzyme, ALDOC is reported to be expressed specifically in the hippocampus and in Purkinje cells of the brain, which makes it a useful point of reference when studying brain-enriched glycolytic metabolism. Orthologues are annotated in mouse and rat, both named Aldoc.
The approved HGNC name is aldolase, fructose-bisphosphate C, and the previous name was aldolase C, fructose-bisphosphate. UniProt lists the protein as fructose-bisphosphate aldolase C. Researchers working on ALDOC commonly place it alongside the other fructose-bisphosphate aldolase isozymes when comparing how glycolytic steps are handled in different tissues.
ALDOC cleaves fructose 1,6-bisphosphate reversibly, so it is relevant to studies of carbohydrate flux in both glycolytic and gluconeogenic directions.
Expression is reported specifically in the hippocampus and Purkinje cells, making ALDOC relevant to energy metabolism in these brain regions.
As a class I fructose-bisphosphate aldolase, ALDOC is studied alongside related family members to compare how aldolase isoforms differ between tissues.
ALDOC acts on fructose 1,6-bisphosphate and fructose 1-phosphate, giving a model for aldol cleavage to dihydroxyacetone phosphate and glyceraldehyde derivatives.
ALDOC catalyses the reversible conversion of fructose 1,6-bisphosphate into two triose phosphates, a key step in glycolysis and gluconeogenesis. It also cleaves fructose 1-phosphate, giving dihydroxyacetone phosphate plus either glyceraldehyde-3-phosphate or glyceraldehyde.
The HGNC-approved name is aldolase, fructose-bisphosphate C. The previous name was aldolase C, fructose-bisphosphate, and UniProt calls the protein fructose-bisphosphate aldolase C. No alternative gene symbols are recorded. The enzyme is classified as EC 4.1.2.13.
Yes. Orthologues of the ALDOC gene are annotated in both mouse and rat, where the gene is named Aldoc. Check the datasheet of any product for its validated reactivity before using it with a particular species.
Other fructose-bisphosphate aldolases and glycolytic enzymes with research products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P09972; product specifications from Assay Genie datasheets.