FGF10
FGF10 (fibroblast growth factor 10) is a secreted, heparin-binding member of the fibroblast growth factor family. It regulates embryonic development, cell proliferation and differentiation, and is required for normal branching morphogenesis. Browse Assay Genie's current range of FGF10 research reagents below, or read on for the biology behind the target.
FGF10 is a secreted signalling protein that plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. It is required for normal branching morphogenesis and may play a role in wound healing. UniProt places it in the heparin-binding growth factors family, and HGNC classifies it among receptor ligands in the fibroblast growth factor family.
The FGF10 gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in processes that include embryonic development, cell growth, morphogenesis, tissue repair, and tumour growth and invasion. The FGF10 protein shows mitogenic activity for keratinising epidermal cells but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7.
Studies of the mouse homologue, Fgf10, suggest that the gene is required for embryonic epidermal morphogenesis, including brain development, lung morphogenesis and the initiation of limb bud formation. The gene is also implicated as a primary factor in wound healing. Rat also has an Fgf10 ortholog, so the target is commonly studied in rodent models of development and tissue repair. Researchers working on FGF10 often compare it with related ligands such as FGF7, as well as with FGF receptors.
FGF10 helps regulate embryonic development, and mouse studies indicate a requirement in brain development and the initiation of limb bud formation.
FGF10 is required for normal branching morphogenesis, and mouse studies link it to lung morphogenesis.
FGF10 may play a role in wound healing and is implicated as a primary factor in tissue repair.
FGF10 is mitogenic for keratinising epidermal cells but essentially inactive on fibroblasts, resembling FGF7.
FGF10 is a secreted growth factor that regulates embryonic development, cell proliferation and cell differentiation. It is required for normal branching morphogenesis and may play a role in wound healing. It is mitogenic for keratinising epidermal cells but essentially inactive on fibroblasts.
FGF10 belongs to the fibroblast growth factor family, which UniProt places within the heparin-binding growth factors. HGNC lists it in the gene group of receptor ligands. Its activity on epidermal cells is similar to that of FGF7, another family member.
Yes. Mouse and rat both have an Fgf10 ortholog, and studies of the mouse gene have shown roles in epidermal morphogenesis, lung morphogenesis and limb bud initiation. Check the datasheet of any product for its validated reactivity.
Other fibroblast growth factors, FGF-binding proteins and FGF receptors relevant to development and tissue repair research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O15520; product specifications from Assay Genie datasheets.