CSN3
CSN3 (casein kappa), also known as kappa-casein or CSN10, is a secreted milk protein that stabilises micelle formation and prevents casein from precipitating in milk. It belongs to the kappa-casein family and is involved in lactation. Browse Assay Genie's current range of CSN3 research reagents below, or read on for the biology behind the target.
CSN3 is the kappa-casein protein, a component of milk. Its recorded function is to stabilise micelle formation, which prevents casein precipitation in milk. In this way CSN3 helps keep the other caseins in a soluble, dispersed state. This is why it is studied in the context of lactation and protein stabilisation. The Alliance of Genome Resources annotates the gene as involved in both processes, and places the protein in the extracellular space. UniProt lists its subcellular location as secreted.
The CSN3 gene encodes a protein that belongs to the kappa-casein family. HGNC classifies it within the secretory calcium-binding phosphoprotein family, a group that also includes other casein genes. Researchers working on the CSN3 protein often consider it alongside related caseins such as CSN1S1 and CSN2, because the caseins act together in milk. Mouse and rat each have an orthologous gene, named Csn3, which allows comparative work on lactation in rodent models.
The approved HGNC name is casein kappa, and the previous name was casein, kappa. The earlier symbol CSN10 is still found in older literature and databases. Searches for a CSN3 antibody, CSN3 ELISA kit or other CSN3 reagents may therefore also turn up this alias, so it is worth checking both symbols when reviewing published work.
CSN3 is involved in lactation, making it a relevant protein for studying how milk proteins are produced and handled.
Kappa-casein stabilises micelle formation and prevents casein precipitation, so CSN3 is a focus for work on milk protein assembly.
The gene is annotated as involved in protein stabilisation, offering a natural example of a secreted protein that keeps others in solution.
Mouse and rat Csn3 orthologs, plus related casein genes, support comparative studies of the casein family.
CSN3 encodes kappa-casein, a secreted milk protein. It stabilises micelle formation and so prevents casein from precipitating in milk. It is also annotated as being involved in lactation and in protein stabilisation.
The HGNC name is casein kappa, with the previous name casein, kappa. The protein is called kappa-casein, and CSN10 is an earlier gene symbol. These names all refer to the same gene, so it helps to search under each.
Yes. Mouse and rat both have an ortholog named Csn3. The protein belongs to the kappa-casein family, and the gene sits in the secretory calcium-binding phosphoprotein family. Check the datasheet of any product for its validated reactivity.
Other casein genes and the casein kinase family, which share naming with CSN3 but are distinct proteins, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P07498; product specifications from Assay Genie datasheets.