IL-26
IL-26 (interleukin 26, also known as AK155) is a secreted member of the IL-10 family of cytokines. It is thought to act in local mucosal immunity and appears to have a pro-inflammatory function. Browse Assay Genie's current range of IL-26 research reagents below, or read on for the biology behind the target.
IL-26 is a secreted cytokine that may play a role in local mechanisms of mucosal immunity and seems to have a pro-inflammatory function. It may also play a role in inflammatory bowel disease. Signalling by IL-26 activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Downstream, it induces expression of SOCS3, TNF and IL-8, drives secretion of IL-8 and IL-10, and increases surface expression of ICAM1. It also decreases the proliferation of intestinal epithelial cells. Its activity is inhibited by heparin.
The IL-26 gene belongs to the interleukin group and the IL-10 family of cytokines, and the encoded protein may function as a homodimer. As a secreted protein, IL-26 acts extracellularly, which makes it relevant to studies of cytokine signalling in epithelial and mucosal settings. Researchers working on the IL-26 protein often examine it alongside other IL-10 family members such as IL-10, IL-19, IL-20, IL-22 and IL-24.
The gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells, and the encoded protein is thought to contribute to the transformed phenotype of T cells after infection by that virus. The alias AK155 reflects this original identification. Together, these features place IL-26 at the interface of antiviral, inflammatory and mucosal biology.
IL-26 may play a role in local mechanisms of mucosal immunity and seems to have a pro-inflammatory function.
IL-26 may play a role in inflammatory bowel disease and decreases the proliferation of intestinal epithelial cells.
IL-26 activates STAT1, STAT3, ERK1/2, JUN and AKT, and induces SOCS3, TNF and IL-8 expression.
IL-26 is overexpressed in herpesvirus samimiri-transformed T cells and may contribute to their transformed phenotype.
IL-26 is a secreted cytokine that may contribute to local mucosal immunity and appears pro-inflammatory. It activates STAT1, STAT3, ERK1/2, JUN and AKT, induces SOCS3, TNF and IL-8, and increases surface ICAM1. It also reduces intestinal epithelial cell proliferation.
IL-26 is the interleukin 26 gene product, with the HGNC symbol IL26 and the alias AK155. UniProt lists the protein as Interleukin-26. It may function as a homodimer, and its activity is inhibited by heparin.
IL-26 belongs to the IL-10 family of cytokines. It may play a role in inflammatory bowel disease, and it was first identified through overexpression in herpesvirus samimiri-transformed T cells. Check the datasheet of any product for its validated reactivity.
Other IL-10 family cytokines and interleukins involved in inflammatory and mucosal signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NPH9; product specifications from Assay Genie datasheets.