PPP2R2B
PPP2R2B (protein phosphatase 2 regulatory subunit Bbeta, also known as PR55-BETA, PR52B and B55beta) is the beta isoform of the B55 regulatory subunit of protein phosphatase 2A. It belongs to the phosphatase 2A regulatory subunit B family, and defects in the gene cause spinocerebellar ataxia 12 (SCA12). Browse Assay Genie's current range of PPP2R2B research reagents below, or read on for the biology behind the target.
Protein phosphatase 2 is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, made up of a catalytic subunit and a constant regulatory subunit, which associates with a variety of regulatory subunits. PPP2R2B encodes one of these variable B subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the catalytic enzyme to a particular subcellular compartment.
The PPP2R2B gene encodes the beta isoform of the B55 subfamily and belongs to the phosphatase 2A regulatory subunit B family. HGNC places it in the WD repeat domain containing group and the protein phosphatase 2 regulatory subunits group. UniProt records the protein in the cytoplasm, cytoskeleton, membranes and mitochondrion, including the mitochondrial outer membrane. Multiple alternatively spliced variants encoding different isoforms have been identified. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity, and it regulates neuronal survival through the balance of mitochondrial fission and fusion.
The gene is also known as PR52B and was previously named protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform. Its alias SCA12 reflects its disease link: defects in this gene cause autosomal dominant spinocerebellar ataxia 12, a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, resulting in poor coordination of speech and body movements. The 5' UTR of some transcript variants contains a CAG trinucleotide repeat of 7-28 copies, which can expand to 55-78 copies in SCA12.
Defects in the PPP2R2B gene cause SCA12, a cerebellar degeneration disorder, making it a key target for studying CAG repeat expansion in the 5' UTR.
As a B55 regulatory subunit, PPP2R2B helps define how PP2A holoenzymes select substrates and modulate catalytic activity.
Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance, linking PP2A regulation to neuronal health.
Within the PP2A holoenzyme, isoform 2 is required to promote proapoptotic activity, and the protein localises to the mitochondrial outer membrane.
PPP2R2B encodes a B regulatory subunit of protein phosphatase 2A. It might modulate substrate selectivity and catalytic activity, and might direct the catalytic enzyme to a particular subcellular compartment. Isoform 2 promotes proapoptotic activity and regulates neuronal survival through mitochondrial fission and fusion balance.
PPP2R2B is also called PR55-BETA, PR52B, B55beta and SCA12. Its HGNC name is protein phosphatase 2 regulatory subunit Bbeta, and it was previously named spinocerebellar ataxia 12. Multiple alternatively spliced variants encode different isoforms, so literature may refer to isoform numbers.
Mouse and rat both have a Ppp2r2b ortholog. In humans, defects in the gene cause autosomal dominant spinocerebellar ataxia 12, associated with CAG repeat expansion from 7-28 copies to 55-78 copies in the 5' UTR of some variants. Check the datasheet of any product for its validated reactivity.
Other PP2A subunits, related Ser/Thr phosphatase catalytic and regulatory subunits with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q00005; product specifications from Assay Genie datasheets.