NUP62
NUP62 (nucleoporin 62, also known as p62) is an FG-repeat nucleoporin and an essential component of the nuclear pore complex, which regulates traffic between the nucleus and the cytoplasm. It also contributes to centrosome function during the mitotic cell cycle. Browse Assay Genie's current range of NUP62 research reagents below, or read on for the biology behind the target.
The nuclear pore complex is a massive structure spanning the nuclear envelope. It forms a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm, and nucleoporins are its main components. NUP62 is an essential member of this assembly. Its N-terminal region is probably involved in nucleocytoplasmic transport, while the C-terminal region is thought to mediate protein-protein interaction through coiled-coil formation. That region promotes association with centrosomes and may anchor the protein to the pore complex. NUP62 associates with the importin alpha/beta complex, which imports proteins that carry nuclear localisation signals.
The NUP62 gene encodes a member of the FG-repeat containing nucleoporins, which localises to the nuclear pore central plug. Multiple transcript variants of the NUP62 gene encode a single protein isoform. UniProt places the protein in the nucleoporin NSP1/NUP62 family and lists its locations as the nuclear pore complex, the nuclear envelope, the centrosome and the spindle pole. The HGNC gene group is Nucleoporins, and the mouse and rat orthologs are both named Nup62.
Beyond transport, NUP62 plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might also be involved in recruiting proteins to the centrosome after nuclear breakdown. This dual role makes the NUP62 protein a useful subject for work on both nuclear pore biology and mitotic organisation. The protein is also known as p62, and the symbol has previously been written as nucleoporin 62kDa. Other aliases include IBSN and SNDI.
NUP62 is an essential component of the nuclear pore complex and sits in the central plug, making it a core subject for studies of pore architecture.
NUP62 associates with the importin alpha/beta complex, which imports proteins bearing nuclear localisation signals, so it is relevant to import mechanisms.
NUP62 regulates centrosome segregation, centriole maturation and spindle orientation, linking the nuclear pore protein to mitotic cell cycle progression.
The C-terminal region is involved in protein-protein interaction, probably through coiled-coil formation, which supports anchorage to the pore complex and association with centrosomes.
NUP62 is an essential component of the nuclear pore complex. Its N-terminal region is probably involved in nucleocytoplasmic transport. It also regulates centrosome segregation, centriole maturation and spindle orientation, and so contributes to mitotic cell cycle progression.
NUP62 is also called p62, nuclear pore glycoprotein p62 and nucleoporin 62kDa. Aliases include IBSN, SNDI, MGC841, FLJ20822 and FLJ43869. According to the NCBI Gene summary, multiple transcript variants encode a single protein isoform.
Yes. Mouse and rat both have an ortholog named Nup62. The human protein belongs to the nucleoporin NSP1/NUP62 family. Check the datasheet of any product for its validated reactivity.
Other nucleoporins and nuclear pore complex components with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P37198; product specifications from Assay Genie datasheets.