LPAR4
LPAR4 (lysophosphatidic acid receptor 4, also known as LPA4, GPR23, P2Y9 and P2RY9) is a cell-membrane G protein-coupled receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. It belongs to the lysophosphatidic acid receptor family. Browse Assay Genie's current range of LPAR4 research reagents below, or read on for the biology behind the target.
LPAR4 is a receptor for lysophosphatidic acid (LPA), a lipid mediator that influences a wide range of cellular activities. On binding LPA, the receptor transduces a signal by increasing intracellular calcium ions and by stimulating adenylyl cyclase activity. Its agonist preference follows a defined rank order of potency: 1-oleoyl-LPA is strongest, followed by 1-stearoyl-, 1-palmitoyl-, 1-myristoyl-, 1-alkyl- and 1-alkenyl-LPA.
The LPAR4 protein is located at the cell membrane and belongs to the G protein-coupled receptor 1 family. In the HGNC classification it sits in the lysophosphatidic acid receptors gene group, alongside family members such as LPAR1, LPAR3 and LPAR5. The LPAR4 gene lies on the X chromosome, and a mouse ortholog, Lpar4, is recognised.
The receptor has carried several names. It was previously designated G protein-coupled receptor 23 (GPR23), and the aliases P2Y9, P2RY9 and P2Y5-LIKE reflect a suggested relationship to the P2Y receptors, which bind purine and pyrimidine nucleotides and couple to G proteins. According to the NCBI Gene summary, the encoded protein may also play a role in monocytic differentiation, making it of interest for studies of LPA signalling and myeloid cell biology.
LPAR4 is a receptor for lysophosphatidic acid, a mediator of diverse cellular activities, so it is a natural subject for studies of lipid signalling.
The receptor raises intracellular calcium and stimulates adenylyl cyclase, providing a model for dissecting calcium and cAMP-linked responses.
NCBI Gene notes that LPAR4 may play a role in monocytic differentiation, which motivates work on myeloid cell development.
A defined agonist rank order, from 1-oleoyl-LPA to 1-alkenyl-LPA, makes LPAR4 useful for comparing ligand selectivity across LPA receptors.
LPAR4 is a cell-membrane receptor for lysophosphatidic acid. Ligand binding transduces a signal by increasing intracellular calcium ions and stimulating adenylyl cyclase activity. It prefers 1-oleoyl-LPA, with potency falling through 1-stearoyl-, 1-palmitoyl-, 1-myristoyl-, 1-alkyl- and 1-alkenyl-LPA.
LPAR4 is also called LPA4, GPR23, P2Y9, P2RY9 and P2Y5-LIKE. The previous name was G protein-coupled receptor 23. The P2Y-style aliases reflect a possible relationship to P2Y nucleotide receptors, although it is classified in the lysophosphatidic acid receptor family.
A mouse ortholog, Lpar4, is recognised, so rodent models can be used to study the receptor; check the datasheet of any product for its validated reactivity. LPAR4 belongs to the G protein-coupled receptor 1 family and the HGNC lysophosphatidic acid receptors group.
Other lysophosphatidic acid receptors from the same HGNC gene group, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q99677; product specifications from Assay Genie datasheets.