PEX19
PEX19 (peroxisomal biogenesis factor 19) is a peroxin required for early peroxisomal biogenesis, acting as both a cytosolic chaperone and an import receptor for peroxisomal membrane proteins. It is also known as HK33, PMP1, PXMP1 and PXF. Browse Assay Genie's current range of PEX19 research reagents below, or read on for the biology behind the target.
PEX19 is necessary for early peroxisomal biogenesis. It acts in two linked roles: as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). In the cytoplasm it binds and stabilises newly synthesised PMPs by interacting with their hydrophobic membrane-spanning domains, then targets them to the peroxisome membrane by binding to the integral membrane protein PEX3.
Beyond its role in organelle assembly, the source annotation records that PEX19 excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. The protein is found in the cytoplasm and at the peroxisome membrane, consistent with its shuttling function. It belongs to the peroxin-19 family, within the HGNC peroxins gene group. The PEX19 gene has mouse and rat orthologs, both named Pex19.
Peroxins (PEXs) are proteins essential for the assembly of functional peroxisomes. Peroxisome biogenesis disorders (PBDs) are genetically heterogeneous, autosomal recessive, lethal diseases with multiple defects in peroxisome function, and they fall into at least 14 complementation groups. Defects in the PEX19 gene cause Zellweger syndrome and peroxisome biogenesis disorder complementation group 14 (PBD-CG14, also known as PBD-CGJ). Alternative splicing produces multiple transcript variants. PEX19 was previously named peroxisomal farnesylated protein.
PEX19 is necessary for early peroxisomal biogenesis, making it a central protein for studying how peroxisomes are assembled.
PEX19 binds newly synthesised PMPs through their hydrophobic membrane-spanning domains and delivers them to PEX3 at the peroxisome membrane.
Defects in PEX19 cause Zellweger syndrome and PBD complementation group 14, linking the protein to lethal peroxisomal disease research.
PEX19 excludes CDKN2A from the nucleus and blocks its interaction with MDM2, which results in active degradation of TP53.
PEX19 is a cytosolic chaperone and import receptor for peroxisomal membrane proteins. It binds and stabilises newly synthesised PMPs via their hydrophobic membrane-spanning domains and targets them to the peroxisome membrane by binding PEX3. It is necessary for early peroxisomal biogenesis.
The HGNC name is peroxisomal biogenesis factor 19, and the previous name was peroxisomal farnesylated protein. Aliases and earlier symbols include HK33, D1S2223E, PMP1, PMPI, PXMP1 and PXF. Alternative splicing gives multiple transcript variants.
Defects in the PEX19 gene cause Zellweger syndrome and peroxisome biogenesis disorder complementation group 14. Mouse and rat both carry a Pex19 ortholog, so rodent models are used; check the datasheet of any product for its validated reactivity.
Other peroxins, the PEX3 docking partner and CDKN2A–MDM2–TP53 pathway proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P40855; product specifications from Assay Genie datasheets.