The PEX19 Antibody (CAB5476) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the PEX19 protein, this antibody allows for easy detection and analysis of PEX19 in various cell types, making it ideal for studies in cell biology and genetics.PEX19 is a crucial player in the formation and maintenance of peroxisomes, organelles involved in lipid metabolism and reactive oxygen species detoxification. Dysregulation of peroxisome biogenesis has been linked to various genetic disorders and metabolic diseases.
This antibody is validated for use in WB, ELISA, IF-P applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
PEX19 Antibody
SKU:
CAB5476
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one phenotype being observed for some complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. Alternative splicing results in multiple transcript variants.
Purification Method
Affinity purification
Gene ID
5824
RRID
AB_2766277
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using PEX19 Rabbit pAb (CAB5476) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
Immunofluorescence analysis of paraffin-embedded mouse liver using PEX19 Rabbit pAb (CAB5476) at dilution of 1:100. Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
![Anti-PEX19 [R02-4Y2] Monoclonal Antibody (AGMB01456)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/272745/677110/anti-pex19-r02-4y2-monoclonal-antibody-agmb01456__67219.1773031583.jpg?c=2 "Anti-PEX19 [R02-4Y2] Monoclonal Antibody (AGMB01456)")
