KHSRP
KHSRP (KH-type splicing regulatory protein, also known as KSRP, FBP2 and FUBP2) is a multifunctional RNA-binding protein. It takes part in transcription, alternative pre-mRNA splicing, mRNA localisation and the degradation of unstable transcripts. Browse Assay Genie's current range of KHSRP research reagents below, or read on for the biology behind the target.
KHSRP acts at several steps of RNA and gene regulation. It binds to the dendritic targeting element and may play a role in mRNA trafficking. It is part of a ternary complex that binds the downstream control sequence (DCS) of the pre-mRNA. It also mediates exon inclusion in transcripts that undergo tissue-specific alternative splicing. In addition, KHSRP may interact with single-stranded DNA from the far-upstream element (FUSE) and may activate gene expression.
KHSRP is also involved in the degradation of inherently unstable mRNAs. These transcripts carry AU-rich elements (AREs) in their 3'-UTR. The protein is thought to recruit the degradation machinery to ARE-containing mRNAs. This links one protein to both the processing and the turnover of RNA. The protein localises to the nucleus and the cytoplasm, which fits its roles in splicing and in mRNA fate. Researchers studying the KHSRP gene or the KHSRP protein often use it as a model for how a single RNA-binding factor can serve several functions.
The KHSRP gene encodes the protein, which UniProt names far upstream element-binding protein 2. It belongs to the KHSRP family. HGNC places the gene in the group of microRNA protein coding host genes. The aliases KSRP, FBP2 and FUBP2 appear throughout the literature, so searches often need to cover all of them. Mouse and rat both have a Khsrp ortholog, which allows comparative work in rodent models.
KHSRP mediates exon inclusion in transcripts subject to tissue-specific alternative splicing, making it relevant to studies of splicing control.
KHSRP is involved in degrading unstable mRNAs containing AU-rich elements in the 3'-UTR, possibly by recruiting degradation machinery.
KHSRP binds the dendritic targeting element and may play a role in mRNA trafficking within the cell.
KHSRP may interact with single-stranded far-upstream element DNA and may activate gene expression, linking it to transcription studies.
KHSRP is a multifunctional RNA-binding protein. It binds the dendritic targeting element, joins a complex on the pre-mRNA downstream control sequence, and promotes exon inclusion in tissue-specifically spliced transcripts. It also contributes to the degradation of unstable ARE-containing mRNAs.
The HGNC name is KH-type splicing regulatory protein. UniProt calls the protein far upstream element-binding protein 2. Aliases include KSRP, FBP2 and FUBP2. Check all of these names when searching the literature, because different papers use different ones.
Yes. Both mouse and rat have an ortholog named Khsrp, so the protein can be studied in rodent systems. Check the datasheet of any product for its validated reactivity.
Other RNA-binding proteins, splicing regulators and mRNA decay factors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q92945; product specifications from Assay Genie datasheets.