ARHGDIB
ARHGDIB (Rho GDP dissociation inhibitor beta) is a cytosolic member of the Rho GDI family that restrains the GDP/GTP exchange cycle of Rho proteins. It is also known as Ly-GDI, RhoGDI2, RAP1GN1, GDIA2 and GDID4. Browse Assay Genie's current range of ARHGDIB research reagents below, or read on for the biology behind the target.
ARHGDIB regulates the GDP/GTP exchange reaction of Rho proteins. It does so by inhibiting the dissociation of GDP from them, which in turn limits the subsequent binding of GTP. Because Rho-family GTP-binding proteins are active only in the GTP-bound state, this places ARHGDIB among the factors that control how long these proteins remain switched off. The protein also regulates reorganisation of the actin cytoskeleton mediated by Rho family members.
Rho proteins and other Ras-related small GTP-binding proteins take part in diverse cellular events, including cell signalling, proliferation, cytoskeletal organisation and secretion. Cycling between the GTP-bound and GDP-bound states is tightly regulated by at least three classes of proteins: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs) and GDP-dissociation inhibitors (GDIs). ARHGDIB belongs to the last class and decreases the rate of GDP dissociation from Ras-like GTPases. UniProt places it in the Rho GDI family, and it is found in the cytosol.
The ARHGDIB gene is also referred to by the names Ly-GDI, RhoGDI2, RAP1GN1, GDIA2 and GDID4, and its previous name was Rho GDP dissociation inhibitor (GDI) beta. HGNC lists it within the gene groups receptor ligands, minor histocompatibility antigens and the Rho GDP dissociation inhibitor family. The mouse ortholog is Arhgdib. Researchers studying the ARHGDIB protein often do so in the context of Rho GTPase regulation and cytoskeletal control.
ARHGDIB inhibits GDP dissociation from Rho proteins, making it a useful focus for studying how the GDP/GTP cycle of small GTPases is controlled.
The protein regulates actin reorganisation mediated by Rho family members, linking it to studies of cytoskeletal remodelling.
As a GDI alongside GAPs and GRFs, ARHGDIB helps researchers dissect how Ras-related GTPases cycle between active and inactive states.
Rho and related GTPases contribute to signalling, proliferation and secretion, and ARHGDIB offers a route to examine their upstream regulation.
ARHGDIB regulates the GDP/GTP exchange reaction of Rho proteins by inhibiting the dissociation of GDP from them and the subsequent binding of GTP. It also regulates reorganisation of the actin cytoskeleton mediated by Rho family members. It localises to the cytosol.
ARHGDIB stands for Rho GDP dissociation inhibitor beta. UniProt names the protein Rho GDP-dissociation inhibitor 2, and aliases include Ly-GDI, RhoGDI2, RAP1GN1, GDIA2 and GDID4. Its previous HGNC name was Rho GDP dissociation inhibitor (GDI) beta.
A mouse ortholog, Arhgdib, is recorded for the human gene. ARHGDIB belongs to the Rho GDI family, and HGNC groups it with the Rho GDP dissociation inhibitor family. Check the datasheet of any product for its validated reactivity.
Other Rho GDP dissociation inhibitors, Rho-family GTPases and cytoskeletal signalling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P52566; product specifications from Assay Genie datasheets.