LMF1
LMF1 (lipase maturation factor 1) is an endoplasmic reticulum membrane protein required for the maturation and transport of active lipoprotein lipase through the secretory pathway. It is also known as TMEM112, TMEM112A, C16orf26 and JFP11. Browse Assay Genie's current range of LMF1 research reagents below, or read on for the biology behind the target.
LMF1 is involved in the maturation of specific proteins in the endoplasmic reticulum. Its best-characterised role is in the maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Rather than acting stoichiometrically, each LMF1 molecule chaperones 50 or more molecules of LPL, so a relatively small amount of this factor supports a much larger pool of active enzyme. Without it, LPL does not reach its functional form, which links the LMF1 protein directly to the control of lipase activity.
The LMF1 gene encodes a protein that belongs to the lipase maturation factor family, and it is predicted to be active in the endoplasmic reticulum membrane, consistent with its role in handling proteins early in the secretory pathway. The mouse ortholog is designated Lmf1. A paralogous family member, LMF2, is also recognised.
Functionally, LMF1 is involved in the triglyceride metabolic process, and it has been implicated in familial lipase maturation factor 1 deficiency. The protein has previously been catalogued as chromosome 16 open reading frame 26 (C16orf26) and transmembrane protein 112 (TMEM112), and the aliases FLJ12681, FLJ22302 and JFP11 also appear in the literature. Researchers studying lipid metabolism, protein folding and secretory trafficking use LMF1 as a model for how a dedicated ER factor can govern the output of a single enzyme class.
LMF1 is involved in the triglyceride metabolic process through its role in producing active lipoprotein lipase.
LMF1 is involved in the maturation of specific proteins in the endoplasmic reticulum, making it a useful model of client-specific maturation.
LMF1 is required for transport of active LPL through the secretory pathway, relevant to studies of enzyme export.
LMF1 is implicated in familial lipase maturation factor 1 deficiency, a focus for genetic and mechanistic investigation.
LMF1 is involved in maturing specific proteins in the endoplasmic reticulum. It is required for the maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway, and each LMF1 molecule chaperones 50 or more LPL molecules.
LMF1 is also known as TMEM112, TMEM112A, C16orf26, JFP11, FLJ12681 and FLJ22302. Its previous HGNC names were chromosome 16 open reading frame 26 and transmembrane protein 112. The official name is lipase maturation factor 1.
LMF1 is implicated in familial lipase maturation factor 1 deficiency and is involved in triglyceride metabolism. A mouse ortholog, Lmf1, exists; check the datasheet of any product for its validated reactivity.
Related lipase maturation factor family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96S06; product specifications from Assay Genie datasheets.