SIGLEC15
SIGLEC15 (sialic acid binding Ig like lectin 15, also known as HsT1361 or CD33L3) is a membrane protein of the SIGLEC family that binds sialylated glycoproteins. It belongs to the immunoglobulin superfamily and is encoded by the human SIGLEC15 gene. Browse Assay Genie's current range of SIGLEC15 research reagents below, or read on for the biology behind the target.
SIGLEC15 is a sialic acid-binding Ig-like lectin that binds sialylated glycoproteins. As a lectin, it recognises sialic acid-containing glycan structures, which allows it to take part in interactions between a cell surface and sialylated partner molecules. UniProt records it as a membrane protein, and NCBI Gene describes it as predicted to be active in the plasma membrane and to be part of a protein-containing complex.
The SIGLEC15 gene encodes a 328-residue protein that belongs to the immunoglobulin superfamily and the SIGLEC family. HGNC places it in the V-set domain containing group and in the sialic acid binding Ig like lectins group. Researchers studying this protein may work with a SIGLEC15 antibody, a SIGLEC15 ELISA kit or recombinant SIGLEC15 protein to examine its expression and ligand binding.
Based on predictions curated by the Alliance of Genome Resources, SIGLEC15 is involved in regulation of actin cytoskeleton organisation, regulation of bone resorption and regulation of osteoclast development. These annotations are predicted rather than experimentally assigned, and they place the protein in studies of bone biology and cytoskeletal control. The protein has also been catalogued as HsT1361 and CD33L3; earlier HGNC names include CD33 antigen-like 3 and CD33 molecule-like 3, reflecting its relationship to the CD33-related Siglecs.
SIGLEC15 binds sialylated glycoproteins, making it a useful subject for studying lectin recognition of sialic acid-containing glycans.
NCBI Gene predicts a role for SIGLEC15 in regulating bone resorption, linking it to studies of bone remodelling.
SIGLEC15 is predicted to take part in regulating osteoclast development, relevant to work on how these bone cells form.
Predicted involvement in regulating actin cytoskeleton organisation makes SIGLEC15 of interest in studies of membrane-associated cytoskeletal control.
SIGLEC15 is a membrane lectin that binds sialylated glycoproteins. NCBI Gene predicts that it is involved in regulating actin cytoskeleton organisation, bone resorption and osteoclast development, and that it is active in the plasma membrane as part of a protein-containing complex.
SIGLEC15 is also known as HsT1361 and CD33L3. Earlier HGNC names are CD33 antigen-like 3 and CD33 molecule-like 3. The approved name is sialic acid binding Ig like lectin 15, and UniProt lists it as Sialic acid-binding Ig-like lectin 15.
SIGLEC15 belongs to the immunoglobulin superfamily and the SIGLEC (sialic acid binding Ig-like lectin) family. HGNC also classes it among V-set domain containing proteins. Mouse and rat orthologs are not given in the data here, so check the datasheet of any product for its validated reactivity.
Other SIGLEC family sialic acid-binding lectins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6ZMC9; product specifications from Assay Genie datasheets.