TULP2
TULP2 (TUB like protein 2, also known as TUBL2 and CT65) is a member of the tubby-like protein family, which belongs to the wider TUB family. Its precise biological function has not been defined, and it is studied as part of this conserved group of proteins. Browse Assay Genie's current range of TULP2 research reagents below, or read on for the biology behind the target.
TULP2 is a member of a family of tubby-like genes (TULPs). According to the NCBI Gene summary, the proteins encoded by this family are of unknown function, so the molecular mechanism of TULP2 has yet to be described. Anyone working with the TULP2 protein should therefore treat it as an area of open investigation and not as a protein with an assigned activity.
What the sources do establish is the family context. Members of the tubby-like family have been identified in plants, vertebrates and invertebrates, which points to a long evolutionary history. The TULP proteins share a conserved C-terminal region of approximately 200 amino acid residues, and UniProt classifies TULP2 within the TUB family on this basis. UniProt records the protein in the cytoplasm and as a secreted protein. The TULP2 gene has a mouse ortholog, Tulp2, which allows comparative work between human and mouse.
The official HGNC name is TUB like protein 2, and the protein is listed in UniProt as tubby-related protein 2. Earlier literature and databases may use the aliases TUBL2 and CT65, or the previous name tubby like protein 2. Checking all of these terms is useful when searching for work on the gene. Because the family is defined by sequence conservation rather than by a characterised shared activity, TULP2 is usually considered alongside its relatives when its biology is discussed.
TULP2 belongs to a family found in plants, vertebrates and invertebrates, making it a useful entry point for studying the tubby-like proteins.
The function of TULP proteins is described as unknown, so TULP2 is a candidate for studies aiming to assign a biological role.
UniProt lists TULP2 in both the cytoplasm and the secreted fraction, which frames questions about where the protein acts and how it is released.
The presence of a mouse Tulp2 ortholog supports comparative work on the conserved C-terminal region shared across the TULP family.
The NCBI Gene summary describes the tubby-like family, including TULP2, as encoding proteins of unknown function. No catalytic or signalling activity is assigned in the sources used here. What is known is that TULP proteins share a conserved C-terminal region of about 200 amino acids.
TULP2 is the HGNC symbol for TUB like protein 2. Aliases and previous symbols include TUBL2 and CT65, the previous name is tubby like protein 2, and UniProt lists the protein as tubby-related protein 2. Searching under all of these names helps when reviewing earlier literature.
The tubby-like family has been identified in plants, vertebrates and invertebrates, and its members share a conserved C-terminal region. TULP2 itself has a mouse ortholog, Tulp2. Check the datasheet of any product for its validated reactivity.
Other tubby-like family members and related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O00295; product specifications from Assay Genie datasheets.