MYBL2
MYBL2, also known as B-MYB or BMYB, is a nuclear transcription factor of the MYB family that regulates cell survival, proliferation and differentiation. It is also called Myb-related protein B and takes part in cell cycle progression. Browse Assay Genie's current range of MYBL2 research reagents below, or read on for the biology behind the target.
MYBL2 is a transcription factor involved in the regulation of cell survival, proliferation and differentiation. It is a nuclear protein that contributes to cell cycle progression, and it possesses both activator and repressor activities. Among its reported targets, MYBL2 transactivates the CLU gene and has been shown to activate the cell division cycle 2 (CDC2), cyclin D1 and insulin-like growth factor-binding protein 5 genes.
The MYBL2 protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle, which links its activity to the core cell cycle machinery. The MYBL2 gene belongs to the MYB family of transcription factor genes and is classed by HGNC within the Myb/SANT domain containing group and among the MMB complex subunits. Two transcript variants encoding different isoforms have been described for the gene. The mouse ortholog is Mybl2.
The gene was originally named v-myb avian myeloblastosis viral oncogene homolog-like 2, and the symbol is now MYB proto-oncogene like 2. The aliases B-MYB and BMYB are widely used in the literature. Researchers studying MYBL2 often examine it alongside its relative MYBL1, as part of work on MYB family control of proliferation and differentiation. Reagents such as a MYBL2 antibody or MYBL2 ELISA kit support this research by allowing the protein to be detected and measured in experimental systems.
MYBL2 is a nuclear protein involved in cell cycle progression and is phosphorylated by cyclin A/CDK2 during S-phase.
MYBL2 has both activator and repressor activities and activates genes including cell division cycle 2, cyclin D1 and IGFBP5.
As a transcription factor, MYBL2 is involved in the regulation of cell survival, proliferation and differentiation.
HGNC lists MYBL2 among MMB complex subunits and Myb/SANT domain containing proteins, making it relevant to complex-level studies.
MYBL2 is a nuclear transcription factor involved in the regulation of cell survival, proliferation and differentiation. It contributes to cell cycle progression, has both activator and repressor activities, and activates genes including CDC2, cyclin D1, IGFBP5 and CLU.
MYBL2 is also called B-MYB or BMYB, and its UniProt name is Myb-related protein B. An earlier name was v-myb avian myeloblastosis viral oncogene homolog-like 2. Two transcript variants encoding different isoforms have been reported for the gene.
A mouse ortholog, Mybl2, is recorded for the gene. MYBL2 belongs to the MYB family of transcription factors, which also includes MYBL1. Check the datasheet of any product for its validated reactivity.
MYB family relatives of MYBL2 with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P10244; product specifications from Assay Genie datasheets.