Description
B-Myb Transcription Factor Activity Assay
The B-MYB Transcription Factor Activity Assay Kit is a reliable tool for measuring the activity of the B-MYB transcription factor in various samples, including cell lysates and tissue homogenates. This kit offers high sensitivity and specificity, allowing for accurate and reproducible results in a wide range of research applications.B-MYB is a key player in regulating cell cycle progression and cell proliferation, making it an important target for studying oncogenesis and cancer progression. By measuring B-MYB activity, researchers can gain valuable insights into the mechanisms underlying these processes and potentially identify new therapeutic targets for cancer treatment.
Overall, the B-MYB Transcription Factor Activity Assay Kit is essential for researchers looking to investigate the role of B-MYB in cellular processes and its implications for various diseases, including cancer. With its high-quality components and user-friendly protocol, this kit is a valuable asset for any laboratory conducting studies on transcription factor activity.
| Product Name: | B-Myb Transcription Factor Activity Assay |
| Product Code: | TFAB00072 |
| Target: | B-Myb |
| Synonyms: | Myb-like protein 2 |
| Reactivity: | Human, Mouse, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie B-Myb transcription factor activity assay allows for the detection and qualitative analysis of B-Myb active transcription factors in eukaryotic nuclear or cell lysates.
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | B-Myb: a transcription factor involved in cell cycle progression. Phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 20q13.1 Cellular Component: nucleoplasm Molecular Function:protein binding; chromatin binding; transcription factor activity Biological Process: transcription, DNA-dependent; regulation of cell cycle; positive regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; G2/M transition of mitotic cell cycle |
| NCBI Summary: | The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013] |
| UniProt Code: | P10244 |
| NCBI GenInfo Identifier: | 127584 |
| NCBI Gene ID: | 4605 |
| NCBI Accession: | P10244.1 |
| UniProt Secondary Accession: | P10244,Q53F07, B2RBS5, B7Z8D9, F8W6N6, |
| UniProt Related Accession: | P10244 |
| Molecular Weight: | 75,865 Da |
| NCBI Full Name: | Myb-related protein B |
| NCBI Synonym Full Names: | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
| NCBI Official Symbol: | MYBL2 |
| NCBI Official Synonym Symbols: | BMYB; B-MYB |
| NCBI Protein Information: | myb-related protein B; myb-like protein 2; v-myb myeloblastosis viral oncogene homolog-like 2 |
| UniProt Protein Name: | Myb-related protein B |
| UniProt Synonym Protein Names: | Myb-like protein 2 |
| Protein Family: | Myb-related protein |
| UniProt Gene Name: | MYBL2 |
| UniProt Entry Name: | MYBB_HUMAN |
