Description
MYB (Phospho-Ser12)Transcription Factor Activity Assay
The MYB Phospho-Ser12 Transcription Factor Activity Assay is a cutting-edge tool for accurately measuring the activity of MYB transcription factor in cellular samples. With its high sensitivity and specificity, this assay provides researchers with reliable and reproducible results, making it an essential tool for studying the role of MYB in various biological processes.MYB is a key transcription factor that plays a critical role in cell growth, differentiation, and proliferation. Its dysregulation has been implicated in a variety of diseases, including cancer and leukemia.
By measuring the phosphorylation status of MYB at Ser12, this assay enables researchers to gain insights into the regulatory mechanisms controlling MYB activity and its impact on cellular functions.Ideal for a wide range of research applications, the MYB Phospho-Ser12 Transcription Factor Activity Assay from AssayGenie is a valuable tool for uncovering the role of MYB in health and disease, paving the way for potential therapeutic interventions.
| Product Name: | MYB (Phospho-Ser12)Transcription Factor Activity Assay |
| Product Code: | TFAB00035 |
| Target: | MYB (Phospho-Ser12) |
| Synonyms: | Proto-oncogene c-Myb |
| Reactivity: | Human, Mouse, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie MYB (Phospho-Ser12) transcription factor activity assay allows for the detection and qualitative analysis of MYB (Phospho-Ser12) active transcription factors in eukaryotic nuclear or cell lysates.
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | Myb: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor; Oncoprotein Chromosomal Location of Human Ortholog: 6q22-q23 Molecular Function:protein binding Biological Process: chromatin remodeling; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of histone H3-K4 methylation; positive regulation of histone H3-K9 methylation; positive regulation of T-helper cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] |
| UniProt Code: | P10242 |
| NCBI GenInfo Identifier: | 2815504 |
| NCBI Gene ID: | 4602 |
| NCBI Accession: | P10242.2 |
| UniProt Secondary Accession: | P10242,P78391, P78392, P78525, P78526, Q14023, Q14024 E9PI07, E9PLZ5, E9PNA4, E9PNL6, E9PRS2, |
| UniProt Related Accession: | P10242 |
| Molecular Weight: | 37,507 Da |
| NCBI Full Name: | Transcriptional activator Myb |
| NCBI Synonym Full Names: | MYB proto-oncogene, transcription factor |
| NCBI Official Symbol: | MYB |
| NCBI Official Synonym Symbols: | efg; Cmyb; c-myb; c-myb_CDS |
| NCBI Protein Information: | transcriptional activator Myb |
| UniProt Protein Name: | Transcriptional activator Myb |
| UniProt Synonym Protein Names: | Proto-oncogene c-Myb |
| Protein Family: | Myb protein |
| UniProt Gene Name: | MYB |
| UniProt Entry Name: | MYB_HUMAN |
