GLI2
GLI2 (GLI family zinc finger 2) is a C2H2-type zinc finger transcription factor of the GLI family that mediates Sonic hedgehog signalling. It is also known as THP2, HPE9 and THP1, and was previously named glioma-associated oncogene family zinc finger 2. Browse Assay Genie's current range of GLI2 research reagents below, or read on for the biology behind the target.
GLI2 is a transcription factor that binds DNA through zinc finger motifs containing conserved H-C links. Members of the GLI family are mediators of Sonic hedgehog (Shh) signalling, and the GLI2 protein is described as activating expression of the patched Drosophila homolog (PTCH) gene. It is also thought to play a role during embryogenesis. Members of this subclass have been implicated as potent oncogenes in embryonal carcinoma cells.
The GLI2 gene encodes a protein of the GLI C2H2-type zinc-finger family, classed by HGNC in the C2H2-type zinc finger gene group. UniProt records GLI2 in the nucleus, the cytoplasm and the primary cilium, and the NCBI Gene summary describes the encoded protein as localising to the cytoplasm. A mouse ortholog, Gli2, is recognised. GLI2 sits alongside related family members GLI1 and GLI3 in the hedgehog pathway.
In a microbial infection context, UniProt notes that GLI2 acts as a transcriptional activator in cells infected with human T-cell leukaemia virus type 1 (HTLV-1), in a Tax-dependent manner. It binds the DNA sequence 5'-GAACCACCCA-3', part of the Tax-responsive element TRE-2S that augments the Tax-dependent HTLV-1 enhancer. Variation in the GLI2 gene is associated with several phenotypes: Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B.
GLI2 mediates Sonic hedgehog signalling and activates PTCH expression, making it a central readout for hedgehog pathway studies.
GLI2 is thought to play a role during embryogenesis, so it is studied in developmental patterning and morphogenesis.
GLI family proteins are implicated as potent oncogenes in embryonal carcinoma cells, which motivates work on GLI2 in tumour biology.
GLI2 is associated with Greig cephalopolysyndactyly, Pallister-Hall syndrome and several polydactyly types, supporting genetic and disease-mechanism research.
GLI2 is a zinc finger transcription factor that binds DNA and mediates Sonic hedgehog signalling. It activates expression of the PTCH gene and is thought to play a role during embryogenesis. UniProt also records a Tax-dependent activator role in HTLV-1-infected cells.
GLI2 is the HGNC symbol for GLI family zinc finger 2. Aliases and previous symbols include THP2, HPE9 and THP1. Earlier names were GLI-Kruppel family member GLI2 and glioma-associated oncogene family zinc finger 2. UniProt lists it as Transcription activator GLI2.
The NCBI Gene summary associates GLI2 with Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. The mouse ortholog is Gli2; check the datasheet of any product for its validated reactivity.
Other GLI family zinc finger proteins and GLI-related targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P10070; product specifications from Assay Genie datasheets.