PAX2
PAX2 (paired box 2, also known as PAX-2 or paired box gene 2) is a nuclear transcription factor of the paired box family. It has a critical role in the development of the urogenital tract, the eyes and the central nervous system. Browse Assay Genie's current range of PAX2 research reagents below, or read on for the biology behind the target.
PAX2 is a transcription factor that may have a role in kidney cell differentiation. It has a critical role in the development of the urogenital tract, the eyes and the CNS. The protein is located in the nucleus, where it acts on gene expression programmes that guide these developing tissues.
The PAX2 gene encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The defining feature of this transcription factor family is the conserved DNA-binding paired box domain. HGNC places PAX2 in the paired boxes group, within the PRD class homeoboxes and pseudogenes. Alternative splicing of the gene results in multiple transcript variants. The mouse ortholog is Pax2.
PAX2 is believed to be a target of transcriptional suppression by the tumour suppressor gene WT1, which links it to a regulatory network involved in kidney development. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia, consistent with its roles in the eye and the urogenital tract. The gene was previously named paired box gene 2, and the symbol PAX-2 is also used in the literature. These properties make the PAX2 protein a common subject in developmental biology and kidney research.
PAX2 may have a role in kidney cell differentiation and is critical for development of the urogenital tract.
PAX2 has a critical role in eye development, and its mutations are associated with optic nerve colobomas.
PAX2 has a critical role in the development of the central nervous system.
PAX2 is thought to be transcriptionally suppressed by the tumour suppressor WT1, making it relevant to studies of gene regulation.
PAX2 is a nuclear transcription factor that may have a role in kidney cell differentiation. It has a critical role in the development of the urogenital tract, the eyes and the central nervous system. It binds DNA through the conserved paired box domain.
PAX2 is also written PAX-2, and its previous name was paired box gene 2. UniProt lists the protein as Paired box protein Pax-2. Alternative splicing of the gene results in multiple transcript variants.
Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. PAX2 is one of many human homologues of the Drosophila gene prd, and the mouse ortholog is Pax2. Check the datasheet of any product for its validated reactivity.
Other paired box transcription factors from the same family, which share the conserved DNA-binding paired box domain.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q02962; product specifications from Assay Genie datasheets.