CA2
CA2, also known as carbonic anhydrase 2, carbonic anhydrase II, CA-II or CAII, is an alpha-carbonic anhydrase that catalyses the reversible hydration of carbon dioxide. It supports pH regulation, bone resorption and fluid secretion in several tissues. Browse Assay Genie's current range of CA2 research reagents below, or read on for the biology behind the target.
CA2 catalyses the reversible hydration of carbon dioxide. It can also hydrate cyanamide to urea. Beyond this core activity, the enzyme stimulates the chloride-bicarbonate exchange activity of SLC26A6, and it contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption.
The enzyme has roles in several physiological processes. It is essential for bone resorption and osteoclast differentiation, and it is involved in regulating fluid secretion into the anterior chamber of the eye. The protein is found in the cytoplasm and at the cell membrane. It belongs to the alpha-carbonic anhydrase family, and the CA2 gene is part of the HGNC carbonic anhydrases gene group. Mouse and rat orthologs are both designated Ca2.
CA2 is one of several carbonic anhydrase isozymes. According to the NCBI Gene summary, defects in this enzyme are associated with osteopetrosis and renal tubular acidosis, which fits its roles in osteoclast function and acid-base handling. Two transcript variants encoding different isoforms have been reported for the gene. Previous names and symbols include carbonic anhydrase II, Car2, CA-II and CAII, which are worth searching when comparing literature on this isozyme.
CA2 is essential for bone resorption and osteoclast differentiation, making it relevant to studies of osteoclast function and osteopetrosis.
Defects in CA2 are associated with renal tubular acidosis, so the enzyme is a focus for work on pH and bicarbonate handling.
CA2 is involved in regulating fluid secretion into the anterior chamber of the eye, linking it to aqueous humour studies.
CA2 contributes to intracellular pH regulation in duodenal upper villous epithelium during proton-coupled peptide absorption.
CA2 catalyses the reversible hydration of carbon dioxide and can also hydrate cyanamide to urea. It stimulates chloride-bicarbonate exchange by SLC26A6, is essential for bone resorption and osteoclast differentiation, and contributes to pH regulation and fluid secretion in specific tissues.
CA2 is also called carbonic anhydrase II, CA-II, CAII or Car2, and its HGNC previous name is carbonic anhydrase II. The NCBI Gene summary reports two transcript variants that encode different isoforms. The enzyme is classified as EC 4.2.1.1.
Defects in CA2 are associated with osteopetrosis and renal tubular acidosis. The gene has mouse and rat orthologs, both named Ca2, so rodent models can be used to study it. Check the datasheet of any product for its validated reactivity.
Other carbonic anhydrase isozymes with products at Assay Genie, useful for comparing family members.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P00918; product specifications from Assay Genie datasheets.