DDR1
DDR1 (discoidin domain receptor tyrosine kinase 1) is a cell surface receptor tyrosine kinase activated by fibrillar collagen. It is also known as RTK6, CD167, NTRK4, PTK3A, NEP, CAK and EDDR1, and it regulates cell attachment to the extracellular matrix. Browse Assay Genie's current range of DDR1 research reagents below, or read on for the biology behind the target.
DDR1 is a tyrosine kinase that acts as a cell surface receptor for fibrillar collagen. Collagen binding triggers a signalling pathway that involves SRC and leads to activation of MAP kinases. Through this route DDR1 regulates cell attachment to the extracellular matrix, matrix remodelling, cell migration, differentiation, survival and proliferation. It up-regulates the matrix metalloproteinases MMP2, MMP7 and MMP9, which facilitates cell migration and wound healing, and it phosphorylates PTPN11.
The DDR1 gene encodes a member of a receptor tyrosine kinase subfamily whose extracellular domain is homologous to the Dictyostelium discoideum protein discoidin I, and whose members are activated by various types of collagen. The protein belongs to the protein kinase superfamily, Tyr protein kinase family, insulin receptor subfamily. It is found at the cell membrane and also in a secreted form. Expression is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract and brain. Alternatively spliced transcript variants encoding different isoforms have been described.
Receptor tyrosine kinases mediate communication between cells and their microenvironment, and DDR1 links collagen in the matrix to cell behaviour. It is required for normal blastocyst implantation during pregnancy, mammary gland differentiation and lactation, and for normal ear morphology and hearing. It promotes smooth muscle cell migration and so contributes to arterial wound healing. DDR1 also plays a role in tumour cell invasion and is significantly overexpressed in several human tumours. Previously named discoidin domain receptor family, member 1, it is related to DDR2, and mouse and rat both carry a Ddr1 ortholog.
DDR1 is a receptor for fibrillar collagen and signals through SRC and MAP kinases, making it a model for matrix-to-cell communication.
DDR1 up-regulates MMP2, MMP7 and MMP9, linking collagen sensing to matrix remodelling, cell migration and wound healing.
DDR1 contributes to tumour cell invasion and is significantly overexpressed in several human tumours.
DDR1 is required for blastocyst implantation, mammary gland differentiation, lactation and normal hearing, and supports arterial wound healing.
DDR1 is a receptor tyrosine kinase that binds fibrillar collagen at the cell surface. Activation involves SRC and MAP kinases, and regulates cell attachment, matrix remodelling, migration, differentiation, survival and proliferation. It also phosphorylates PTPN11 and up-regulates MMP2, MMP7 and MMP9.
DDR1 is also called RTK6, CD167, NTRK4, PTK3A, NEP, CAK and EDDR1. UniProt lists the protein name as epithelial discoidin domain-containing receptor 1. The gene was previously named discoidin domain receptor family, member 1, and alternatively spliced transcript variants encode different isoforms.
DDR1 is significantly overexpressed in several human tumours and contributes to tumour cell invasion. Mouse and rat each have a Ddr1 ortholog. Check the datasheet of any product for its validated reactivity.
Another discoidin domain receptor tyrosine kinase with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q08345; product specifications from Assay Genie datasheets.