SORBS1
SORBS1 (sorbin and SH3 domain containing 1) is a CBL-associated adaptor protein that links CBL to the insulin receptor and supports insulin-stimulated glucose transport. It is also known as CAP, ponsin, SH3D5, sh3p12 and KIAA1296. Browse Assay Genie's current range of SORBS1 research reagents below, or read on for the biology behind the target.
SORBS1 plays a role in the tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. This adaptor function places the protein within insulin signalling, and it is required for insulin-stimulated glucose transport. SORBS1 is also involved in the formation of actin stress fibres and focal adhesions, connecting signalling events to cytoskeletal organisation.
The SORBS1 gene encodes a CBL-associated protein, and the SORBS1 protein is assigned by HGNC to the SH3 domain containing gene group. UniProt records a broad subcellular distribution: adherens junctions, the cell membrane, the cytoskeleton, focal adhesions, the nucleus and the nuclear matrix. Alternative splicing results in multiple transcript variants, so researchers working with SORBS1 antibody or SORBS1 ELISA kit reagents should consider which variants are relevant to their question.
The protein was previously named SH3-domain protein 5 (ponsin), which explains the aliases SH3D5 and ponsin still found in the literature, alongside CAP. Mutations in the SORBS1 gene may be associated with human disorders of insulin resistance, according to the NCBI Gene summary. Mouse and rat both carry an orthologous gene named Sorbs1, which allows the biology to be studied in common rodent models.
SORBS1 links CBL to the insulin receptor, making it a focus for studies of how insulin signals are transmitted.
The protein is required for insulin-stimulated glucose transport, so it is relevant to research on cellular glucose uptake.
Mutations in the gene may be associated with human disorders of insulin resistance, supporting genetic and mechanistic investigation.
SORBS1 is involved in forming actin stress fibres and focal adhesions, connecting it to cytoskeletal and cell junction biology.
SORBS1 links CBL to the insulin receptor, which contributes to tyrosine phosphorylation of CBL. It is required for insulin-stimulated glucose transport and is involved in forming actin stress fibres and focal adhesions. Check the datasheet of any product for its validated reactivity.
SORBS1 is also called CAP, ponsin, SH3D5, sh3p12, KIAA1296 and FLJ12406. The former HGNC name was SH3-domain protein 5 (ponsin). Alternative splicing produces multiple transcript variants of the gene.
The NCBI Gene summary notes that mutations in SORBS1 may be associated with human disorders of insulin resistance. Orthologous genes named Sorbs1 are annotated in both mouse and rat, so rodent models can be used to study its function.
Insulin signalling components, CBL pathway partners and other SH3 domain adaptors with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BX66; product specifications from Assay Genie datasheets.