CUBN
CUBN (cubilin, also known as IFCR, gp280 and MGA1) is an endocytic receptor that facilitates the uptake of lipoproteins, vitamins and iron-related proteins. It serves as the receptor for intrinsic factor-vitamin B12 complexes in absorptive epithelia. Browse Assay Genie's current range of CUBN research reagents below, or read on for the biology behind the target.
CUBN is an endocytic receptor that plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. It acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, haemoglobin, ALB, TF and SCGB1A1. Together with AMN, it mediates endocytosis of the CBLIF-cobalamin complex. Cubilin also binds MB, kappa and lambda light chains and APOA1, and ligand binding requires calcium.
The CUBN gene encodes a large membrane protein whose receptor role is supported by the presence of 27 CUB domains. The protein is found at the apical cell membrane, in coated pits, in endosomes and at the lysosome membrane, consistent with its function in internalising bound ligands. Cubilin is an important transporter in several absorptive epithelia, including the intestine, renal proximal tubules and the embryonic yolk sac. The mouse and rat orthologues are both named Cubn.
The previous HGNC name, cubilin (intrinsic factor-cobalamin receptor), reflects its best-known ligand, and the aliases IFCR, gp280 and MGA1 appear in the literature. Mutations in the CUBN gene may play a role in autosomal recessive megaloblastic anaemia. Cubilin may also contribute to development of the peri-implantation embryo through internalisation of APOA1 and cholesterol, and it binds LGALS3 at the maternal-foetal interface. These properties make the CUBN protein a useful subject for studies of epithelial transport and nutrient uptake.
CUBN is the receptor for intrinsic factor-vitamin B12 complexes and works with AMN to mediate endocytosis of the CBLIF-cobalamin complex.
Cubilin acts with LRP2 to endocytose ligands such as albumin, transferrin and haemoglobin in absorptive epithelia including the kidney.
CUBN facilitates uptake of high-density lipoproteins, APOA1 and transferrin, linking it to lipoprotein, vitamin and iron metabolism.
Cubilin is active in the embryonic yolk sac, may support the peri-implantation embryo via APOA1 and cholesterol, and binds LGALS3.
CUBN is an endocytic receptor that facilitates uptake of lipoproteins, vitamins and iron-related proteins. It works with LRP2 for ligands such as HDL, albumin and transferrin, and with AMN for the CBLIF-cobalamin complex. Ligand binding requires calcium.
CUBN is also known as IFCR, gp280 and MGA1. Its previous HGNC name was cubilin (intrinsic factor-cobalamin receptor), which refers to its role as the receptor for intrinsic factor-vitamin B12 complexes.
NCBI Gene reports that mutations in CUBN may play a role in autosomal recessive megaloblastic anaemia. Mouse and rat both have an orthologous Cubn gene; check the datasheet of any product for its validated reactivity.
Co-receptors, ligands and pathway partners of cubilin involved in epithelial endocytosis, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O60494; product specifications from Assay Genie datasheets.