FZD7
FZD7 (frizzled class receptor 7, also known as Frizzled-7 or FzE3) is a seven-transmembrane receptor for Wnt signalling proteins. It belongs to the frizzled family of G protein-coupled receptors and also acts as a receptor for C. difficile toxin TcdB in the colonic epithelium. Browse Assay Genie's current range of FZD7 research reagents below, or read on for the biology behind the target.
FZD7 is a member of the frizzled gene family, whose members encode 7-transmembrane domain proteins that act as receptors for Wnt signalling proteins. The FZD7 protein sits in the cell membrane and the endosome membrane. In the colonic epithelium it has a second, microbial role: it serves as a receptor for Clostridioides difficile toxin TcdB.
The FZD7 protein has a typical frizzled architecture. It carries an N-terminal signal sequence, 10 cysteine residues characteristic of the cysteine-rich extracellular domain of Fz family members, seven putative transmembrane domains, and an intracellular C-terminal tail containing a PDZ domain-binding motif. UniProt places it in the G protein-coupled receptor Fz/Smo family, and HGNC classifies the FZD7 gene within the Class F frizzled group of G protein-coupled receptors. The mouse ortholog is Fzd7.
The gene has appeared under several earlier names, including frizzled homolog 7 (Drosophila) and frizzled family receptor 7, and the alias FzE3. In disease-related work, NCBI Gene notes that FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human oesophageal carcinomas. This makes FZD7 a point of interest for researchers studying Wnt/beta-catenin signalling and receptor-toxin interactions.
FZD7 is a 7-transmembrane receptor for Wnt signalling proteins, so it is a natural focus for studies of how Wnt signals are received at the cell surface.
FZD7 expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human oesophageal carcinomas.
FZD7 acts as a receptor for C. difficile toxin TcdB in the colonic epithelium, linking it to research on toxin entry.
As a Class F frizzled GPCR found at the cell and endosome membranes, FZD7 is relevant to work on receptor localisation and structure.
FZD7 is a 7-transmembrane receptor for Wnt signalling proteins. Its expression may enhance beta-catenin-mediated signals and downregulate APC function in poorly differentiated human oesophageal carcinomas. In the colonic epithelium it also acts as a receptor for C. difficile toxin TcdB.
The HGNC name is frizzled class receptor 7, and UniProt lists the protein as Frizzled-7. The alias FzE3 is also used. Earlier names include frizzled (Drosophila) homolog 7 and frizzled family receptor 7, reflecting the gene's discovery as a homolog of the Drosophila frizzled gene.
FZD7 has a mouse ortholog, Fzd7. It belongs to the G protein-coupled receptor Fz/Smo family and the Class F frizzled group, alongside FZD1, FZD4 and FZD5. Check the datasheet of any product for its validated reactivity.
Other frizzled receptors in the Class F GPCR group that mediate Wnt signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O75084; product specifications from Assay Genie datasheets.