GBP4
GBP4 (guanylate binding protein 4, also known as Mpa2) is an interferon-inducible GTPase that contributes to innate immunity against bacterial, viral and protozoan pathogens. It also acts as a negative regulator of the antiviral response through IRF7. Browse Assay Genie's current range of GBP4 research reagents below, or read on for the biology behind the target.
GBP4 is an interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens. Like other guanylate-binding proteins, it is induced by interferon and hydrolyses GTP to both GDP and GMP. Alongside its role in pathogen defence, GBP4 negatively regulates the antiviral response by inhibiting activation of the IRF7 transcription factor, which suggests it helps to restrain interferon-driven signalling as well as contribute to it.
The GBP4 protein belongs to the TRAFAC class dynamin-like GTPase superfamily, in the GB1/RHD3 GTPase family and the GB1 subfamily. HGNC places the GBP4 gene in the guanylate binding proteins gene group. UniProt records its subcellular location as the Golgi apparatus membrane, the cytoplasm, the nucleus and the perinuclear region of the cytoplasm. The mouse ortholog is Gbp4, which is useful for researchers who want to study the protein in murine models of infection and immunity.
The name Mpa2 is a recognised alias for the gene. Because GBP4 is inducible by interferon and is linked to both antiviral defence and regulation of IRF7, it is a relevant target for work on interferon-stimulated genes and on how cells tune their innate immune responses. Researchers studying GBP4 often consider it alongside other family members such as GBP1 and GBP2, which share the guanylate-binding protein classification.
GBP4 is an interferon-inducible GTPase involved in innate immunity against bacterial, viral and protozoan pathogens.
GBP4 negatively regulates the antiviral response by inhibiting activation of the IRF7 transcription factor.
As a guanylate-binding protein induced by interferon, GBP4 is a useful readout of interferon-driven gene induction.
GBP4 hydrolyses GTP to both GDP and GMP, making it a model for dynamin-like GTPase activity.
GBP4 is an interferon-inducible GTPase that contributes to innate immunity against bacterial, viral and protozoan pathogens. It hydrolyses GTP to GDP and GMP. It also negatively regulates the antiviral response by inhibiting activation of the IRF7 transcription factor.
The HGNC approved name is guanylate binding protein 4, and UniProt lists the protein as guanylate-binding protein 4. Mpa2 is a recognised alias for the gene. Searches for the GBP4 gene or GBP4 protein should therefore also consider Mpa2 in the literature.
A mouse ortholog, Gbp4, is recognised. GBP4 belongs to the GB1 subfamily of the GB1/RHD3 GTPase family, within the dynamin-like GTPase superfamily. For species reactivity, check the datasheet of any product for its validated reactivity.
Other guanylate-binding proteins from the same interferon-inducible GTPase group.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96PP9; product specifications from Assay Genie datasheets.