ART3
ART3 (ADP-ribosyltransferase 3, also known as ARTC3) is a cell membrane ecto-ADP-ribosyltransferase of the Arg-specific ADP-ribosyltransferase family. It is annotated as modifying proteins by ADP-ribosylation of arginine residues. Browse Assay Genie's current range of ART3 research reagents below, or read on for the biology behind the target.
ART3 is an arginine-specific ADP-ribosyltransferase. According to the NCBI Gene summary, the encoded protein catalyses a reversible reaction that modifies proteins by adding or removing ADP-ribose at an arginine residue, thereby regulating the function of the modified protein. UniProt classifies it as ecto-ADP-ribosyltransferase 3, assigns it EC 2.4.2.31 and places it at the cell membrane.
The ART3 gene belongs to the Arg-specific ADP-ribosyltransferase family, a group that HGNC lists as the ADP-ribosyltransferase family. Researchers working on the ART3 protein should note that the HGNC name carries the qualifier "inactive", so the catalytic status of the protein is a point to consider when designing experiments. The gene summary also reports that multiple transcript variants encoding different isoforms have been found, and that an ADP-ribosyltransferase pseudogene is located on chromosome 11.
ART3 was previously named ADP-ribosyltransferase 3 and also appears under the alias ARTC3. A mouse ortholog, Art3, is recorded. Related family members with pages at Assay Genie include ART1 and ART4, which are useful comparators when studying arginine-directed ADP-ribosylation at the cell surface.
ART3 belongs to the enzymes that add or remove ADP-ribose on arginine residues, a reversible modification that regulates the function of target proteins.
As a cell membrane ecto-ADP-ribosyltransferase, ART3 is relevant to studies of surface-associated protein modification.
ART3 sits within the Arg-specific ADP-ribosyltransferase family, allowing comparison of family members and their catalytic status.
Multiple transcript variants encoding different isoforms are reported for the ART3 gene, making isoform-aware expression studies relevant.
ART3 is described as an arginine-specific ADP-ribosyltransferase. It catalyses a reversible reaction that adds or removes ADP-ribose on an arginine residue of a protein, regulating the function of the modified protein. UniProt places it at the cell membrane and assigns EC 2.4.2.31.
ART3 is also known as ARTC3, and its UniProt name is ecto-ADP-ribosyltransferase 3. The HGNC full name is ADP-ribosyltransferase 3 (inactive). The NCBI Gene summary reports multiple transcript variants encoding different isoforms, so check which isoform a reagent recognises.
A mouse ortholog, Art3, is recorded for the human gene. No rat ortholog is given in the data used here. The gene also has a related pseudogene on chromosome 11. Check the datasheet of any product for its validated reactivity.
Other ADP-ribosyltransferase family members with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q13508; product specifications from Assay Genie datasheets.