CD300LG
CD300LG (CD300 molecule like family member g, also known as CLM9 and Trem4) is a type I cell surface glycoprotein of the CD300 family. It is a receptor that may mediate L-selectin-dependent lymphocyte rolling. Browse Assay Genie's current range of CD300LG research reagents below, or read on for the biology behind the target.
CD300LG is a receptor that may mediate L-selectin-dependent lymphocyte rolling. It binds SELL (L-selectin) in a calcium-dependent manner, and the UniProt annotation also records binding to lymphocytes. These properties place the CD300LG protein in the context of leukocyte adhesion and trafficking, although its function is described as probable rather than fully established.
CD300LG belongs to the CD300 family, listed by HGNC within the V-set domain containing gene group. As NCBI Gene notes, members of the CD300-like (CD300L) family are widely expressed on haematopoietic cells. All CD300L proteins are type I cell surface glycoproteins that contain a single immunoglobulin (Ig) V-like domain. UniProt lists the protein in the apical cell membrane, the basolateral cell membrane and the membrane of multivesicular body endosomes.
The official protein name in UniProt is CMRF35-like molecule 9, and the CD300LG gene has also been referred to as CLM9 and Trem4. Earlier HGNC names include CD300 antigen like family member G and CD300 molecule-like family member g. The mouse ortholog is Cd300lg. Researchers studying CD300LG often do so alongside other CD300 family members and other cell surface receptors involved in lymphocyte biology.
CD300LG may mediate L-selectin-dependent lymphocyte rolling, making it a candidate for studies of leukocyte adhesion and trafficking.
CD300LG binds SELL in a calcium-dependent manner, providing a defined receptor-ligand pair for binding and cation-dependence work.
As a CD300 family member with a single Ig V-like domain, CD300LG supports comparative studies of CD300L receptors.
UniProt places CD300LG at apical and basolateral membranes and multivesicular body membranes, relevant to polarised localisation and trafficking research.
CD300LG is a receptor that may mediate L-selectin-dependent lymphocyte rolling. It binds SELL in a calcium-dependent manner and also binds lymphocytes, according to UniProt. Its role is described as possible, so researchers should treat its function as still being characterised.
The UniProt protein name is CMRF35-like molecule 9. Aliases and previous symbols include CLM9 and Trem4, and earlier HGNC names include CD300 antigen like family member G. Check these synonyms when searching literature, and check the datasheet of any product for its validated reactivity.
A mouse ortholog, Cd300lg, is recorded for the human gene. CD300LG belongs to the CD300 family, whose members are type I cell surface glycoproteins with a single Ig V-like domain. Check the datasheet of any product for its validated reactivity.
Other CD molecules and cell surface receptors of the immune system with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6UXG3; product specifications from Assay Genie datasheets.