CD101
CD101 (CD101 molecule, also known as V7 and IGSF2) is a membrane protein of the immunoglobulin superfamily that acts as an inhibitor of T-cell proliferation. UniProt lists it as immunoglobulin superfamily member 2, and the gene was previously named immunoglobulin superfamily, member 2. Browse Assay Genie's current range of CD101 research reagents below, or read on for the biology behind the target.
CD101 plays a role as an inhibitor of T-cell proliferation induced by CD3. It reduces expression of IL2RA on activated T-cells and limits secretion of IL-2. It also inhibits the tyrosine kinases that are required for IL-2 production and cellular proliferation. In addition, CD101 inhibits phosphorylation of phospholipase C-gamma-1 (PLCG1) and the subsequent CD3-induced changes in intracellular free calcium, and it prevents nuclear translocation of nuclear factor of activated T-cells.
CD101 has also been linked to the inhibition of T-cell proliferation through IL-10 secretion by cutaneous dendritic cells. UniProt notes that it may be a marker of CD4(+) CD56(+) leukaemic tumour cells. The CD101 protein is a membrane protein. NCBI Gene reports that it is located in extracellular exosomes. Predicted functions include involvement in cell surface receptor signalling, T cell homeostasis, positive regulation of myeloid leukocyte differentiation and response to insulin.
In HGNC the CD101 gene belongs to the CD molecules, V-set domain containing and I-set domain containing groups. It is also known as V7 and IGSF2, the latter reflecting its former name, immunoglobulin superfamily, member 2. The mouse ortholog is Cd101, which allows the biology of this immune regulator to be examined in murine models.
CD101 inhibits CD3-induced T-cell proliferation, IL-2 secretion and IL2RA expression, making it relevant to studies of how T-cell activation is restrained.
It inhibits PLCG1 phosphorylation, CD3-induced calcium changes and nuclear translocation of nuclear factor of activated T-cells, so it is useful for dissecting T-cell receptor signalling.
CD101 is implicated in inhibition of T-cell proliferation via IL-10 secretion by cutaneous dendritic cells, linking it to dendritic cell-mediated immune control.
UniProt reports CD101 as a possible marker of CD4(+) CD56(+) leukaemic tumour cells, supporting its study in haematological malignancy.
CD101 inhibits T-cell proliferation induced by CD3. It lowers IL2RA expression and IL-2 secretion, inhibits tyrosine kinases needed for IL-2 production, blocks PLCG1 phosphorylation and calcium changes, and prevents nuclear translocation of nuclear factor of activated T-cells.
CD101 is also known as V7 and IGSF2. The HGNC full name is CD101 molecule, the UniProt protein name is immunoglobulin superfamily member 2, and the previous gene name was immunoglobulin superfamily, member 2. All refer to the same gene and protein.
A mouse ortholog, Cd101, is recorded; no rat ortholog is given in the data. UniProt notes that CD101 may be a marker of CD4(+) CD56(+) leukaemic tumour cells. Check the datasheet of any product for its validated reactivity.
Other CD molecules, immunoglobulin superfamily members and immune cell markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q93033; product specifications from Assay Genie datasheets.