BCL2L11
BCL2L11, also known as BIM, BOD, BimL, BimEL and BimS, is a BH3-only member of the Bcl-2 family that induces apoptosis and anoikis. It acts as an apoptotic activator and is linked to neuronal and lymphocyte cell death. Browse Assay Genie's current range of BCL2L11 research reagents below, or read on for the biology behind the target.
BCL2L11 (Bcl-2-like protein 11, commonly called BIM) induces apoptosis and anoikis. It belongs to the Bcl-2 family, whose members form hetero- or homodimers and act as anti- or pro-apoptotic regulators in a wide range of cellular activities. BCL2L11 contains a Bcl-2 homology domain 3 (BH3) and has been shown to interact with other Bcl-2 family members, where it acts as an apoptotic activator. UniProt places the protein in the endomembrane system and at the mitochondrion.
The BCL2L11 gene produces several alternatively spliced transcript variants, and the resulting isoforms differ in their activity. Isoform BimL is more potent than isoform BimEL. Isoforms Bim-alpha1, Bim-alpha2 and Bim-alpha3 induce apoptosis, but less potently than BimEL, BimL and BimS, and Bim-alpha3 may act through a caspase-mediated pathway. Isoform Bim-gamma also induces apoptosis, whereas isoforms BimAC and BimABC lack this ability. This makes isoform identity an important consideration when designing a BCL2L11 antibody or BCL2L11 protein experiment.
Expression of the gene can be induced by nerve growth factor (NGF) and by the forkhead transcription factor FKHR-L1, which suggests a role in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart, Bcl2l11, indicated that the gene is an essential initiator of apoptosis in thymocyte negative selection. HGNC classifies it in the BH3-only gene group, and its previous name was BCL2-like 11 (apoptosis facilitator). A rat ortholog, also named Bcl2l11, is recorded.
BCL2L11 is a BH3-only activator of apoptosis and anoikis that interacts with other Bcl-2 family members.
Mouse studies identify Bcl2l11 as an essential initiator of apoptosis in thymocyte negative selection.
Induction of BCL2L11 expression by nerve growth factor points to a role in neuronal apoptosis.
As a BH3 domain protein, BCL2L11 helps define how pro- and anti-apoptotic family members regulate cell fate.
BCL2L11 induces apoptosis and anoikis. It contains a BH3 domain, interacts with other Bcl-2 family members and acts as an apoptotic activator. Its expression can be induced by NGF and FKHR-L1, suggesting roles in neuronal and lymphocyte apoptosis.
BCL2L11 is also called BIM and BOD, and alternative splicing yields isoforms such as BimEL, BimL and BimS. They differ in potency: BimL is more potent than BimEL, while BimAC and BimABC cannot induce apoptosis. Check the datasheet of any product for its validated reactivity.
Yes. Mouse and rat both have an ortholog named Bcl2l11. Transgenic work on the mouse gene indicated that it is an essential initiator of apoptosis in thymocyte negative selection, supporting its role in lymphocyte biology.
Other Bcl-2 family members and BCL-named proteins involved in apoptosis and cell-fate regulation.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O43521; product specifications from Assay Genie datasheets.