ZFAND2A is a member of the AN1-type zinc finger group. Current knowledge of its function rests largely on predictions rather than direct experiment. It is predicted to enable zinc ion binding and to be involved in the proteasome-mediated, ubiquitin-dependent protein catabolic process, as well as in protein targeting to the endoplasmic reticulum (ER).

The NCBI Gene summary also predicts that ZFAND2A acts upstream of or within the cellular response to arsenic-containing substances and the positive regulation of proteasomal ubiquitin-dependent protein catabolic process. It is predicted to be part of the proteasome complex and to be active in the endoplasmic reticulum. UniProt lists the protein in the cytoplasm and the nucleus, and the gene summary predicts a nuclear location.

The human ZFAND2A gene encodes AN1-type zinc finger protein 2A, which has the previous name zinc finger, AN1-type domain 2A and the alias AIRAP. The gene is orthologous to mouse and rat Zfand2a. These annotations place ZFAND2A in the study of proteostasis, proteasome function and stress responses to arsenic-containing compounds. It is a useful target for researchers who want to examine how AN1-type zinc finger proteins connect stress signalling to protein turnover. As the annotations are predicted, experimental work is still needed to confirm them.