STK33
STK33 (serine/threonine kinase 33) is a CAMK-family serine/threonine protein kinase required for spermatid differentiation and male fertility. It phosphorylates fibrous sheath proteins and the intermediate filament protein vimentin. Browse Assay Genie's current range of STK33 research reagents below, or read on for the biology behind the target.
STK33 is a serine/threonine protein kinase that is required for spermatid differentiation and male fertility. During spermatogenesis it promotes sperm flagella assembly by phosphorylating the fibrous sheath proteins AKAP3 and AKAP4. It also phosphorylates vimentin (VIM), and in doing so regulates the dynamic behaviour of the intermediate filament cytoskeleton. The NCBI Gene summary describes it as enabling protein serine/threonine kinase activity and as involved in peptidyl-threonine phosphorylation, spermatogenesis and negative regulation of protein metabolic process.
The human STK33 gene encodes a protein that belongs to the protein kinase superfamily, in the CAMK Ser/Thr protein kinase family and the CaMK subfamily. HGNC places it in the STK33 family kinases gene group. UniProt records the STK33 protein in the cytoplasm, the cytoskeleton and the perinuclear region. NCBI Gene further predicts that it is located in the manchette, a structure associated with spermatid development, and that it is active in the cytoplasm and nucleus. The mouse ortholog is Stk33.
STK33 has been implicated in several human conditions. NCBI Gene lists colorectal cancer, depressive disorder and spermatogenic failure 93 as disease associations. The last of these fits the kinase's established role in sperm flagella assembly and male fertility. Researchers studying STK33 typically focus on its cytoskeletal substrates, its function in the male germ line and its wider role in kinase signalling. They may use an STK33 antibody or an STK33 ELISA kit to examine its expression and abundance.
STK33 is required for spermatid differentiation and male fertility, and spermatogenic failure 93 is linked to the gene.
STK33 promotes flagella assembly by phosphorylating the fibrous sheath proteins AKAP3 and AKAP4 during spermatogenesis.
By phosphorylating vimentin, STK33 regulates the dynamic behaviour of the intermediate filament cytoskeleton.
STK33 is implicated in colorectal cancer and depressive disorder, making it a candidate for disease-association work.
STK33 is a serine/threonine kinase required for spermatid differentiation and male fertility. It phosphorylates AKAP3 and AKAP4 to promote sperm flagella assembly, and it phosphorylates vimentin to regulate the dynamic behaviour of the intermediate filament cytoskeleton.
The HGNC symbol is STK33 and the approved name is serine/threonine kinase 33. No aliases or previous symbols are listed. It belongs to the STK33 family kinases gene group and, within the protein kinase superfamily, to the CaMK subfamily.
NCBI Gene lists colorectal cancer, depressive disorder and spermatogenic failure 93 as associations for STK33. A mouse ortholog, Stk33, exists. Check the datasheet of any product for its validated reactivity.
Other serine/threonine kinases that share the STK nomenclature with STK33.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9BYT3; product specifications from Assay Genie datasheets.