The STK33 Monoclonal Antibody (CAB19803) is a valuable tool for researchers studying STK33, a protein kinase involved in cell growth and division. This antibody, generated in mice, is highly specific and reacts with human samples, making it ideal for use in Western blot and immunofluorescence applications. By targeting the STK33 protein, this antibody allows for the detection and analysis of STK33 expression in various cell types, offering insights into its role in cellular processes.
STK33 is a key player in cell proliferation and survival, making it a promising target for cancer research and drug development. Its dysregulation has been implicated in tumorigenesis and tumor progression, highlighting the need for further investigation into its functions. By studying STK33 with this antibody, researchers can uncover potential therapeutic strategies for treating cancer and other diseases related to abnormal cell growth.
Product Name:
STK33 Rabbit Monoclonal Antibody
SKU:
CAB19803
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 399-514 of human STK33 (Q9BYT3).
cytoplasm, nucleus, perinuclear region of cytoplasm
Calculated MW:
58kDa
Observed MW:
65kDa
Serine/threonine protein kinase (STK33) is a 524-residue kinase that belongs to the calcium/calmodulin-dependent family of kinases. STK33 exhibits differential expression in normal and malignant cancer tissue, including hepatocellular carcinoma. STK33 expression is required in the context of mutant KRAS, the most commonly mutated human oncogene, to maintain for cellular viability and proliferation. STK33 depletion via modulation of interacting proteins results in proteasome-mediated degradation of STK33 in human cancer cells, triggering apoptosis.
Purification Method:
Affinity purification
Gene ID:
65975
Clone Number:
ARC2330
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of SH-SY5Y cells, using STK33 Rabbit mAb (CAB19803) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
