TUSC2
TUSC2 (tumour suppressor 2, mitochondrial calcium regulator) is a small protein of the TUSC2 family, also known as FUS1, PAP, C3orf11 and PDAP2. It is a candidate tumour suppressor encoded within the 3p21.3 region and is predicted to act in the mitochondrion. Browse Assay Genie's current range of TUSC2 research reagents below, or read on for the biology behind the target.
TUSC2, or tumour suppressor candidate 2, may function as a tumour suppressor. According to UniProt, it may inhibit colony formation, cause G1 arrest and ultimately induce apoptosis in cells that are homozygously deficient for the 3p21.3 120-kb region. The wording is cautious: the annotation describes a candidate role rather than an established mechanism, which is reflected in the protein's name.
The TUSC2 gene sits at 3p21.31 and encodes a small protein belonging to the TUSC2 family. Its subcellular location is not annotated in UniProt. The NCBI Gene summary, however, predicts that the protein is active in the mitochondrion and is involved in the regulation of mitochondrial membrane potential. This is consistent with the current HGNC name, which describes the protein as a mitochondrial calcium regulator. The mouse ortholog is Tusc2.
The NCBI Gene summary also predicts involvement in the inflammatory response. It further predicts that TUSC2 acts upstream of or within several processes, including natural killer cell differentiation, neutrophil-mediated killing of gram-negative bacterium and regulation of cytokine production. These are predictions from the Alliance of Genome Resources rather than experimentally defined roles.
The protein has several names. FUS1 and C3orf11 refer to its position in the 3p21.3 region, while PAP and PDAP2 reflect an earlier designation as PDGFA associated protein 2. Researchers studying TUSC2 will find these aliases in older literature, so searches should cover all of them.
TUSC2 is a candidate tumour suppressor that may inhibit colony formation and cause G1 arrest in cells lacking the 3p21.3 region.
Loss of the 3p21.3 region is linked to G1 arrest and eventual apoptosis in the UniProt annotation, which makes TUSC2 relevant to cell fate studies.
TUSC2 is predicted to be active in the mitochondrion and to regulate mitochondrial membrane potential, so it is relevant to mitochondrial physiology.
Predicted roles in inflammatory response, natural killer cell differentiation and cytokine production make TUSC2 a candidate for immunology research.
TUSC2 may function as a tumour suppressor. UniProt reports that it may inhibit colony formation, cause G1 arrest and ultimately induce apoptosis in cells deficient for the 3p21.3 120-kb region. NCBI also predicts roles in mitochondrial membrane potential and inflammatory response.
TUSC2 is also called FUS1, PAP, C3orf11 and PDAP2. Earlier names include PDGFA associated protein 2 and tumour suppressor candidate 2. The current HGNC name is tumour suppressor 2, mitochondrial calcium regulator.
A mouse ortholog, Tusc2, is recorded for the human gene, so mouse models can be used to study it. No rat ortholog is given in the data supplied. Check the datasheet of any product for its validated reactivity.
Other tumour suppressor, apoptosis and mitochondrial targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O75896; product specifications from Assay Genie datasheets.