PRSS23
PRSS23 (serine protease 23) is a secreted member of the trypsin family of serine proteases, classed in the peptidase S1 family. It is also known by the aliases SPUVE and SIG13, and by the previous name protease, serine 23. Browse Assay Genie's current range of PRSS23 research reagents below, or read on for the biology behind the target.
PRSS23 is a serine protease, assigned the EC number 3.4.21.- that covers serine endopeptidases. UniProt places it in the peptidase S1 family, and the NCBI Gene summary describes the gene as encoding a conserved member of the trypsin family of serine proteases. The mature protein is annotated as secreted. No detailed functional annotation, substrate list or physiological pathway is recorded in the UniProt entry, so the specific role of PRSS23 is best established from the primary literature.
The human PRSS23 gene is catalogued by HGNC as serine protease 23 within the serine proteases gene group. The encoded protein is also referred to as SPUVE and SIG13, and earlier nomenclature used the name protease, serine 23. Alternative splicing of the gene is reported to give rise to multiple transcript variants, which is worth bearing in mind when designing experiments to detect the PRSS23 protein or its transcripts. Orthologues are present in mouse and rat, both named Prss23, consistent with the description of the gene as conserved.
The NCBI Gene summary notes that, in mouse studies, mRNA levels of this gene decreased after ovulation was induced. This observation links Prss23 expression to a reproductive context in the mouse, although the summary does not define the mechanism. Related trypsin-like serine proteases, including other members of the PRSS gene group, are often studied alongside PRSS23 when researchers compare protease family members.
PRSS23 is a conserved trypsin-family serine protease of the peptidase S1 family, making it a subject for studies of secreted protease function.
Mouse studies reported lower Prss23 mRNA levels after induced ovulation, pointing to research interest in its regulation in reproductive tissues.
Alternative splicing yields multiple transcript variants, so PRSS23 is relevant to work on isoform-specific expression and transcript regulation.
As a member of the serine protease gene group with mouse and rat orthologues, PRSS23 supports cross-species and cross-family comparisons.
PRSS23 is a secreted serine protease of the trypsin family, belonging to peptidase S1. The available UniProt entry has no detailed function annotation, so its specific substrates and physiological roles are not defined in the source data and should be checked in the primary literature.
PRSS23 is also known as SPUVE and SIG13, and was previously named protease, serine 23. The NCBI Gene summary states that alternative splicing results in multiple transcript variants, so more than one transcript can arise from the gene.
Yes. The NCBI Gene summary describes the gene as a conserved member of the trypsin family, and mouse and rat orthologues are both named Prss23. In mouse, Prss23 mRNA levels were reported to fall after induced ovulation. Check the datasheet of any product for its validated reactivity.
Other PRSS-group serine proteases and trypsin-family members that are often studied alongside PRSS23.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95084; product specifications from Assay Genie datasheets.