BIRC7
BIRC7 (baculoviral IAP repeat containing 7) is a member of the inhibitor of apoptosis protein (IAP) family that blocks etoposide-induced apoptosis and protects cells from natural killer cell-mediated killing. It is also known as ML-IAP, mliap, KIAP and RNF50. Browse Assay Genie's current range of BIRC7 research reagents below, or read on for the biology behind the target.
BIRC7 is an anti-apoptotic protein of the IAP family. Functionally, it blocks etoposide-induced apoptosis and protects against natural killer (NK) cell-mediated killing. The protein contains a single copy of a baculovirus IAP repeat (BIR) together with a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, whereas the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone.
The human BIRC7 gene encodes a protein that UniProt places in the nucleus, cytoplasm and Golgi apparatus. Alternative splicing of the gene results in multiple transcript variants. The BIRC7 protein carries a RING domain and is assigned the E3 ubiquitin ligase activity EC 2.3.2.27, consistent with its HGNC classification among RING finger E3 ubiquitin protein ligases. HGNC also lists the gene among baculoviral IAP repeat containing genes and among microRNA protein coding host genes. The mouse ortholog is Birc7.
BIRC7 has been described under several names, including ML-IAP, mliap, KIAP and RNF50, and was previously named baculoviral IAP repeat-containing 7. In disease research, elevated levels of the encoded protein may be associated with cancer progression and may play a role in chemotherapy sensitivity, which makes BIRC7 a frequent subject in studies of apoptosis resistance. Other IAP family members include BIRC2, BIRC3 and BIRC6.
BIRC7 inhibits apoptosis through its caspase-interacting BIR domain, making it a useful subject for studying how IAP proteins restrain cell death.
Elevated BIRC7 levels may be associated with cancer progression, so the protein is studied as a possible factor in tumour biology.
BIRC7 blocks etoposide-induced apoptosis and may influence chemotherapy sensitivity, prompting research into drug response and resistance mechanisms.
BIRC7 protects against natural killer cell-mediated killing, which is relevant to work on how cells resist innate immune cytotoxicity.
BIRC7 is an inhibitor of apoptosis protein. It blocks etoposide-induced apoptosis and protects against natural killer cell-mediated killing. Its BIR domain is essential for inhibitory activity and interacts with caspases, while its RING finger domain sometimes enhances the antiapoptotic effect but cannot inhibit apoptosis alone.
BIRC7 is also called ML-IAP, mliap, KIAP and RNF50, and was previously named baculoviral IAP repeat-containing 7. Alternative splicing of the BIRC7 gene produces multiple transcript variants, so researchers should consider which form of the protein their experiment addresses.
Elevated levels of BIRC7 may be associated with cancer progression and may play a role in chemotherapy sensitivity. A mouse ortholog, Birc7, exists. Check the datasheet of any product for its validated reactivity.
Other baculoviral IAP repeat containing proteins and IAP family members involved in apoptosis regulation.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96CA5; product specifications from Assay Genie datasheets.