LGALS14
LGALS14 (galectin 14, also known as PPL13 and CLC2) is a member of the galectin family of beta-galactoside-binding lectins. The protein binds beta-galactoside and lactose and is described as a strong inducer of T-cell apoptosis. Browse Assay Genie's current range of LGALS14 research reagents below, or read on for the biology behind the target.
LGALS14 is a lectin that binds beta-galactoside and lactose. UniProt annotates it as a strong inducer of T-cell apoptosis, which links this galectin to the regulation of T-cell survival. UniProt lists its subcellular location as the nucleus.
The LGALS14 gene is predominantly expressed in the placenta. The encoded protein belongs to the galectin (galaptin/S-lectin) family, whose members contain one or two carbohydrate recognition domains able to bind beta-galactoside. The UniProt entry names the protein placental protein 13-like, in keeping with its placental expression. Two alternatively spliced transcript variants encoding distinct isoforms have been observed, which is worth bearing in mind when designing experiments around this LGALS14 gene.
The gene was formerly named lectin, galactoside-binding, soluble, 14, and is also known by the aliases PPL13 and CLC2. HGNC places it in the galectins gene group, alongside other family members such as LGALS12, LGALS13, LGALS2, LGALS4 and LGALS8. Researchers studying placental biology, glycan recognition and T-cell regulation may encounter LGALS14 under any of these names.
The gene is predominantly expressed in placenta, making LGALS14 a relevant galectin for studies of placental tissue.
LGALS14 is annotated as a strong inducer of T-cell apoptosis, so it is of interest in work on T-cell survival.
The protein binds beta-galactoside and lactose, supporting research into carbohydrate recognition by the galectin family.
As a member of the galectin family, LGALS14 allows comparison of carbohydrate recognition domains and isoforms across galectins.
LGALS14 is a galectin that binds beta-galactoside and lactose. UniProt describes it as a strong inducer of T-cell apoptosis. The gene is predominantly expressed in placenta, and the protein is annotated as located in the nucleus.
LGALS14 is also called galectin 14, placental protein 13-like, PPL13 and CLC2. Its earlier HGNC name was lectin, galactoside-binding, soluble, 14. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.
The data supplied list no mouse or rat ortholog for LGALS14, so cross-species conservation should not be assumed. It belongs to the galectin family, whose members share carbohydrate recognition domains that bind beta-galactoside. Check the datasheet of any product for its validated reactivity.
Other galectin family members and beta-galactoside-binding lectins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8TCE9; product specifications from Assay Genie datasheets.