CD52
CD52 (CD52 molecule) is a small cell membrane protein, also known as CAMPATH-1 antigen and listed under the aliases HE5, EDDM5 and CDW52. UniProt annotates it as a protein that may carry and orient carbohydrate. Browse Assay Genie's current range of CD52 research reagents below, or read on for the biology behind the target.
CD52 is a membrane-associated protein whose UniProt function annotation is cautious: it may play a role in carrying and orienting carbohydrate, and it may also have a more specific role. The protein is therefore generally described in terms of the carbohydrate it presents at the cell surface, rather than through a defined catalytic or signalling mechanism.
The NCBI Gene summary, provided by the Alliance of Genome Resources, adds that CD52 is involved in positive regulation of cytosolic calcium ion concentration. It is predicted to be located in the extracellular region and plasma membrane, and predicted to be active in the sperm midpiece. UniProt lists the cell membrane as its subcellular location. Researchers studying the CD52 protein will usually work with it as a cell-surface molecule.
The CD52 gene is classed by HGNC within the CD molecules group, and its approved name is CD52 molecule. The previous name, CD52 antigen (CAMPATH-1 antigen), reflects the name still used in the literature and in UniProt, and the gene has also been recorded as HE5, EDDM5 and CDW52. Orthologous genes are named Cd52 in both mouse and rat, which allows comparative work across rodent models. Reagents such as a CD52 antibody or CD52 ELISA kit are typically used to study this surface molecule.
UniProt proposes that CD52 may carry and orient carbohydrate, making it relevant to studies of glycosylated molecules at the cell membrane.
CD52 is involved in positive regulation of cytosolic calcium ion concentration, so it is of interest in work on intracellular calcium dynamics.
As a member of the HGNC CD molecules group, CD52 is studied as a cell-surface marker alongside other CD antigens.
CD52 is predicted to be active in the sperm midpiece, which makes it a candidate for investigation in sperm cell biology.
UniProt states that CD52 may play a role in carrying and orienting carbohydrate, and may have a more specific role. The NCBI Gene summary adds that it is involved in positive regulation of cytosolic calcium ion concentration. Its precise function is not fully defined in these sources.
CD52 is the approved symbol for the CD52 molecule. UniProt names the protein CAMPATH-1 antigen, and earlier names or aliases include CD52 antigen, HE5, EDDM5 and CDW52. All of these refer to the same gene and protein.
Yes. Mouse and rat both carry an ortholog named Cd52, so the gene can be studied in common rodent models. Check the datasheet of any product for its validated reactivity before choosing a reagent for a given species.
Other CD molecules and cell-surface markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P31358; product specifications from Assay Genie datasheets.