EDA
EDA (ectodysplasin A, also known as EDA1, XLHED, ED1-A1 and EDA-A1) is a type II membrane protein of the tumour necrosis factor family. It acts as a homotrimer and may take part in cell-cell signalling during the development of ectodermal organs. Browse Assay Genie's current range of EDA research reagents below, or read on for the biology behind the target.
EDA is a type II membrane protein that belongs to the tumour necrosis factor family. The membrane-bound form can be cleaved by furin to produce a secreted form, so the protein is found both at the cell membrane and in the extracellular space. It acts as a homotrimer, as is typical of TNF family ligands, and may be involved in cell-cell signalling during the development of ectodermal organs. According to UniProt, it binds only to the receptor EDA2R.
The EDA gene encodes ectodysplasin-A. HGNC places it in the tumour necrosis factor superfamily and also lists it among the microRNA protein coding host genes. Several transcript variants encoding many different isoforms have been reported for the gene, and aliases such as EDA-A1, EDA-A2, ED1-A1 and ED1-A2 appear in the literature. Researchers studying a particular form should check which isoform an EDA antibody, EDA ELISA kit or EDA protein reagent is intended to recognise. The mouse ortholog is Eda.
Defects in the EDA gene cause ectodermal dysplasia, anhidrotic, also known as X-linked hypohidrotic ectodermal dysplasia (XLHED). This is reflected in the previous gene names, ectodermal dysplasia 1, anhidrotic and oligodontia 1, and in symbols such as HED, XHED and ED1. Because of this link, EDA is widely used in studies of ectodermal development and of signalling through its receptor, EDA2R.
EDA may be involved in cell-cell signalling during the development of ectodermal organs, making it a focus for developmental biology studies.
Defects in the EDA gene cause anhidrotic ectodermal dysplasia, also called X-linked hypohidrotic ectodermal dysplasia.
As a TNF family homotrimer that is cleaved by furin, EDA is a useful model for membrane-bound and secreted ligand forms.
EDA binds only to the receptor EDA2R, which makes the pair a defined ligand-receptor system for signalling research.
EDA is a TNF family type II membrane protein that acts as a homotrimer. It may be involved in cell-cell signalling during the development of ectodermal organs. Furin can cleave it to give a secreted form, and UniProt reports that it binds only to the receptor EDA2R.
EDA is also called ectodysplasin A, EDA1, XLHED, HED, XHED, ED1, ED1-A1, ED1-A2, EDA-A1, EDA-A2, EDA2 and ODT1. Older names include ectodermal dysplasia 1, anhidrotic and oligodontia 1. Several transcript variants encode many different isoforms.
Defects in EDA cause ectodermal dysplasia, anhidrotic, also known as X-linked hypohidrotic ectodermal dysplasia. The mouse ortholog is Eda. Check the datasheet of any product for its validated reactivity.
The EDA receptor EDA2R and other tumour necrosis factor family targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q92838; product specifications from Assay Genie datasheets.