SCARB1
SCARB1 (scavenger receptor class B member 1, also known as SR-BI, SRB1, CLA-1, CLA1 and CD36L1) is a plasma membrane receptor for high density lipoprotein (HDL) cholesterol. It mediates cholesterol transfer to and from HDL and also acts as a viral entry factor. Browse Assay Genie's current range of SCARB1 research reagents below, or read on for the biology behind the target.
SCARB1 is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL, linking the receptor to lipoprotein handling at the cell surface. UniProt places it at the cell membrane, including caveolae.
Beyond lipid transfer, SCARB1 serves as a receptor for the hepatitis C virus glycoprotein E2 and facilitates cell entry by the virus. It is also reported to facilitate entry of the human coronavirus SARS-CoV-2, acting as an entry cofactor through HDL binding. This makes the SCARB1 protein a point of overlap between lipid biology and virology.
The SCARB1 gene belongs to the CD36 family and is classified by HGNC in the scavenger receptors gene group. Its earlier names include CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1 and scavenger receptor class B, member 1, and it is also written SR-BI, SRB1, CLA-1 and CLA1. The mouse and rat orthologs are both named Scarb1, which allows the receptor to be studied across common model species.
SCARB1 is a cell surface receptor for HDL cholesterol and mediates cholesterol transfer to and from HDL.
SCARB1 is a receptor for hepatitis C virus glycoprotein E2 and facilitates cell entry by the virus.
SCARB1 acts as an entry cofactor for SARS-CoV-2 through HDL binding, making it relevant to studies of coronavirus infection.
As a CD36 family member in the scavenger receptor gene group, SCARB1 is studied alongside related membrane receptors.
SCARB1 is a plasma membrane receptor for HDL cholesterol and mediates cholesterol transfer to and from HDL. It is also a receptor for hepatitis C virus glycoprotein E2 and facilitates cell entry by the virus and by SARS-CoV-2.
SCARB1 is also called SR-BI, SRB1, CLA-1, CLA1 and CD36L1. Earlier names were CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1 and scavenger receptor class B, member 1. Searching under any of these aliases may help locate relevant literature.
Yes. Mouse and rat both have an ortholog named Scarb1. Human SCARB1 belongs to the CD36 family. Researchers working in rodent models can therefore study the receptor in those species; check the datasheet of any product for its validated reactivity.
Other scavenger receptors and related membrane proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q8WTV0; product specifications from Assay Genie datasheets.