MAS1L
MAS1L (MAS1 proto-oncogene like, G protein-coupled receptor) is a cell-membrane receptor of the class A orphan group of G protein-coupled receptors. It is also known as MAS-L, MRG and dJ994E9.2, and was previously named MAS1 oncogene-like. Browse Assay Genie's current range of MAS1L research reagents below, or read on for the biology behind the target.
MAS1L is predicted to enable G protein-coupled receptor activity and to be involved in the G protein-coupled receptor signalling pathway. These assignments are predictions rather than experimentally defined functions, and no UniProt functional annotation is currently provided for the protein. The receptor is located in the plasma membrane, consistent with the cell membrane localisation recorded in UniProt, where it would be positioned to relay extracellular signals through G protein-coupled signalling.
The MAS1L gene encodes the protein listed in UniProt as Mas-related G protein-coupled receptor MRG. It belongs to the G protein-coupled receptor 1 family and, within it, the Mas subfamily. HGNC places it in the gene group of G protein-coupled receptors, class A orphans, a classification used for receptors whose endogenous ligands have not been established. Researchers studying this MAS1L protein should therefore treat its signalling role as open to investigation.
The official name, MAS1 proto-oncogene like, G protein-coupled receptor, reflects its relationship to MAS1, and an earlier name was MAS1 oncogene-like. Alternative designations include MAS-L, MRG and dJ994E9.2. Because the nomenclature varies between databases and publications, searching under several of these names helps when reviewing literature on the MAS1L gene.
MAS1L is a class A orphan receptor, making it relevant to studies seeking to characterise receptors without established ligands.
MAS1L is predicted to take part in G protein-coupled receptor signalling pathways, providing a subject for signal transduction research.
As a member of the Mas subfamily of the GPCR 1 family, MAS1L supports comparative work with related receptors such as MAS1.
MAS1L is located at the cell membrane, which makes it a candidate for studies of receptor trafficking and plasma membrane expression.
MAS1L is predicted to enable G protein-coupled receptor activity and to participate in G protein-coupled receptor signalling. It is located in the plasma membrane. As a class A orphan receptor, its endogenous ligand and precise function are not defined in the sources used here.
MAS1L stands for MAS1 proto-oncogene like, G protein-coupled receptor. Aliases include MAS-L, MRG and dJ994E9.2, and a previous name was MAS1 oncogene-like. UniProt lists the protein as Mas-related G protein-coupled receptor MRG.
MAS1L belongs to the G protein-coupled receptor 1 family, Mas subfamily. HGNC classifies it among class A orphan G protein-coupled receptors. Mouse and rat orthologs are not specified in the data here, so check the datasheet of any product for its validated reactivity.
Other Mas-related receptors and similarly named targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P35410; product specifications from Assay Genie datasheets.