PCSK7
PCSK7 (proprotein convertase subtilisin/kexin type 7, also known as PC7, PC8, LPC and SPC7) is a membrane-bound serine endoprotease of the peptidase S8 family. It processes proproteins by cleaving at basic amino acid residues, most likely in the constitutive secretory pathway. Browse Assay Genie's current range of PCSK7 research reagents below, or read on for the biology behind the target.
PCSK7 is a serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognising the RXXX[KR]R consensus motif. It is thought to function in the constitutive secretory pathway. The enzyme is one of the seven basic amino acid-specific members of the proprotein convertase family, which cleave their substrates at single or paired basic residues. Known or suspected substrates include proalbumin, and PCSK7 is thought to be responsible for activating the HIV envelope glycoproteins gp160 and gp140.
The PCSK7 gene encodes a type 1 membrane-bound protease that is expressed in many tissues, including neuroendocrine tissue, liver, gut and brain. The protein undergoes an initial autocatalytic processing event in the endoplasmic reticulum, then sorts to the trans-Golgi network through endosomes. There a second autocatalytic event takes place and catalytic activity is acquired. Its UniProt classification places it in the peptidase S8 family, and HGNC lists it in the proprotein convertase subtilisin/kexin family, alongside PCSK1, PCSK2, PCSK5, PCSK6 and PCSK9.
Beyond precursor processing, the PCSK7 gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. Orthologous Pcsk7 genes are present in mouse and rat, which allows the protein to be studied in rodent models.
PCSK7 is a trans-Golgi network protease that likely acts in the constitutive secretory pathway, making it a useful subject for studying precursor maturation.
The enzyme cleaves at paired basic residues in an RXXX[KR]R motif and can process proalbumin, so it is studied as a precursor-processing protease.
PCSK7 is thought to activate the HIV envelope glycoproteins gp160 and gp140, linking it to research on viral glycoprotein maturation.
The gene plays a role in regulating iron metabolism, and a translocation involving it is associated with B-cell lymphoma.
PCSK7 is a serine endoprotease that cleaves proproteins at paired basic amino acids, recognising the RXXX[KR]R motif. It likely functions in the constitutive secretory pathway and can process proalbumin. It is also thought to activate HIV gp160 and gp140 envelope glycoproteins.
PCSK7 is the HGNC symbol for proprotein convertase subtilisin/kexin type 7. Aliases include PC7, PC8, LPC and SPC7. Searching under any of these names should help locate literature on the same gene and protein, which UniProt lists as Q16549.
Mouse and rat both carry an orthologous Pcsk7 gene. In humans, a t(11;14)(q23;q32) translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. The gene also plays a role in regulating iron metabolism. Check the datasheet of any product for its validated reactivity.
Other proprotein convertase subtilisin/kexin family members that process precursors in the secretory pathway.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q16549; product specifications from Assay Genie datasheets.